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Proliferation of human malignant astrocytomas is dependent on Ras activation.
Guha A, Feldkamp MM, Lau N, Boss G, Pawson A. Guha A, et al. Among authors: lau n. Oncogene. 1997 Dec 4;15(23):2755-65. doi: 10.1038/sj.onc.1201455. Oncogene. 1997. PMID: 9419966
Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model.
Ding H, Shannon P, Lau N, Wu X, Roncari L, Baldwin RL, Takebayashi H, Nagy A, Gutmann DH, Guha A. Ding H, et al. Among authors: lau n. Cancer Res. 2003 Mar 1;63(5):1106-13. Cancer Res. 2003. PMID: 12615729
Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.
Kimmelman AC, Qiao RF, Narla G, Banno A, Lau N, Bos PD, Nuñez Rodriguez N, Liang BC, Guha A, Martignetti JA, Friedman SL, Chan AM. Kimmelman AC, et al. Among authors: lau n. Oncogene. 2004 Jun 24;23(29):5077-83. doi: 10.1038/sj.onc.1207662. Oncogene. 2004. PMID: 15064720
Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model.
Shannon P, Sabha N, Lau N, Kamnasaran D, Gutmann DH, Guha A. Shannon P, et al. Among authors: lau n. Am J Pathol. 2005 Sep;167(3):859-67. doi: 10.1016/S0002-9440(10)62057-3. Am J Pathol. 2005. PMID: 16127163 Free PMC article.
Aberrant G protein signaling in nervous system tumors.
Woods SA, Marmor E, Feldkamp M, Lau N, Apicelli AJ, Boss G, Gutmann DH, Guha A. Woods SA, et al. Among authors: lau n. J Neurosurg. 2002 Sep;97(3):627-42. doi: 10.3171/jns.2002.97.3.0627. J Neurosurg. 2002. PMID: 12296648 Review.
Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression.
Lau N, Uhlmann EJ, Von Lintig FC, Nagy A, Boss GR, Gutmann DH, Guha A. Lau N, et al. Int J Oncol. 2003 Jan;22(1):195-200. Int J Oncol. 2003. PMID: 12469204
Expression and regulation of neuropilin-1 in human astrocytomas.
Ding H, Wu X, Roncari L, Lau N, Shannon P, Nagy A, Guha A. Ding H, et al. Among authors: lau n. Int J Cancer. 2000 Nov 15;88(4):584-92. doi: 10.1002/1097-0215(20001115)88:4<584::aid-ijc11>3.0.co;2-t. Int J Cancer. 2000. PMID: 11058875
Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma.
Lau N, Feldkamp MM, Roncari L, Loehr AH, Shannon P, Gutmann DH, Guha A. Lau N, et al. J Neuropathol Exp Neurol. 2000 Sep;59(9):759-67. doi: 10.1093/jnen/59.9.759. J Neuropathol Exp Neurol. 2000. PMID: 11005256
Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.
Feldkamp MM, Lau N, Guha A. Feldkamp MM, et al. Among authors: lau n. Oncogene. 1999 Dec 9;18(52):7514-26. doi: 10.1038/sj.onc.1203105. Oncogene. 1999. PMID: 10602510
Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens.
Feldkamp MM, Lala P, Lau N, Roncari L, Guha A. Feldkamp MM, et al. Among authors: lau n. Neurosurgery. 1999 Dec;45(6):1442-53. doi: 10.1097/00006123-199912000-00034. Neurosurgery. 1999. PMID: 10598712
Normal control samples included white matter specimens distal to tumors (n = 5), a sample obtained during a lobectomy for treatment of epilepsy (n = 1), and cultured fetal human astrocytes (n = 1). ...
Normal control samples included white matter specimens distal to tumors (n = 5), a sample obtained during a lobectomy for treatment o …
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