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A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic.
Lau YF, Tang LH, Ooi EE. Lau YF, et al. Vaccine. 2009 Feb 25;27(9):1354-64. doi: 10.1016/j.vaccine.2008.12.048. Epub 2009 Jan 15. Vaccine. 2009. PMID: 19150474 Free PMC article.
Induction of protective immunity against influenza A/Jiangxi-Donghu/346/2013 (H10N8) in mice.
Kuah LF, Tang LH, Sutton T, Lim JH, Sin WL, Lamirande E, Subbarao K, Lau YF. Kuah LF, et al. Among authors: lau yf. J Gen Virol. 2017 Feb;98(2):155-165. doi: 10.1099/jgv.0.000683. Epub 2017 Mar 13. J Gen Virol. 2017. PMID: 27983474 Free PMC article.
The magnitude of local immunity in the lungs of mice induced by live attenuated influenza vaccines is determined by local viral replication and induction of cytokines.
Lau YF, Santos C, Torres-VĂ©lez FJ, Subbarao K. Lau YF, et al. J Virol. 2011 Jan;85(1):76-85. doi: 10.1128/JVI.01564-10. Epub 2010 Oct 20. J Virol. 2011. PMID: 20962087 Free PMC article.
Activation of the innate immune system provides broad-spectrum protection against influenza A viruses with pandemic potential in mice.
Lau YF, Tang LH, Ooi EE, Subbarao K. Lau YF, et al. Virology. 2010 Oct 10;406(1):80-7. doi: 10.1016/j.virol.2010.07.008. Epub 2010 Jul 27. Virology. 2010. PMID: 20667572 Free PMC article.
An adjuvant for the induction of potent, protective humoral responses to an H5N1 influenza virus vaccine with antigen-sparing effect in mice.
Lau YF, Tang LH, McCall AW, Ooi EE, Subbarao K. Lau YF, et al. J Virol. 2010 Sep;84(17):8639-49. doi: 10.1128/JVI.00596-10. Epub 2010 Jun 10. J Virol. 2010. PMID: 20538850 Free PMC article.
Epidemiologic analysis of respiratory viral infections among Singapore military servicemen in 2016.
Lau YF, Koh WV, Kan C, Dua PA, Lim AE, Liaw CJ, Gao QH, Chng J, Lee VJ, Tan BH, Loh JP. Lau YF, et al. BMC Infect Dis. 2018 Mar 12;18(1):123. doi: 10.1186/s12879-018-3040-x. BMC Infect Dis. 2018. PMID: 29529993 Free PMC article.
Influenza B outbreak among influenza-vaccinated welfare home residents in Singapore.
Win MK, Chow A, Chen M, Lau YF, Ooi EE, Leo YS. Win MK, et al. Among authors: lau yf. Ann Acad Med Singap. 2010 Jun;39(6):448-52. Ann Acad Med Singap. 2010. PMID: 20625620
Complete protection against lethal challenge of novel H7N9 virus with heterologous inactivated H7 vaccine in mice.
Tang LH, Lim JH, Kuah LF, Lau YF. Tang LH, et al. Among authors: lau yf. Vaccine. 2014 Sep 22;32(42):5375-8. doi: 10.1016/j.vaccine.2014.07.087. Epub 2014 Aug 15. Vaccine. 2014. PMID: 25130540
Seasonal influenza infection and live vaccine prime for a response to the 2009 pandemic H1N1 vaccine.
Chen GL, Lau YF, Lamirande EW, McCall AW, Subbarao K. Chen GL, et al. Among authors: lau yf. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1140-5. doi: 10.1073/pnas.1009908108. Epub 2011 Jan 3. Proc Natl Acad Sci U S A. 2011. PMID: 21199945 Free PMC article.
The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding.
Qi L, Kash JC, Dugan VG, Jagger BW, Lau YF, Sheng ZM, Crouch EC, Hartshorn KL, Taubenberger JK. Qi L, et al. Among authors: lau yf. Virology. 2011 Apr 10;412(2):426-34. doi: 10.1016/j.virol.2011.01.029. Epub 2011 Feb 18. Virology. 2011. PMID: 21334038 Free PMC article.
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