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An assessment of clinically useful measures of the consequences of treatment.
Laupacis A, Sackett DL, Roberts RS. Laupacis A, et al. N Engl J Med. 1988 Jun 30;318(26):1728-33. doi: 10.1056/NEJM198806303182605. N Engl J Med. 1988. PMID: 3374545 No abstract available.
Atrial fibrillation in patients with cryptogenic stroke.
Gladstone DJ, Spring M, Dorian P, Panzov V, Thorpe KE, Hall J, Vaid H, O'Donnell M, Laupacis A, Côté R, Sharma M, Blakely JA, Shuaib A, Hachinski V, Coutts SB, Sahlas DJ, Teal P, Yip S, Spence JD, Buck B, Verreault S, Casaubon LK, Penn A, Selchen D, Jin A, Howse D, Mehdiratta M, Boyle K, Aviv R, Kapral MK, Mamdani M; EMBRACE Investigators and Coordinators. Gladstone DJ, et al. N Engl J Med. 2014 Jun 26;370(26):2467-77. doi: 10.1056/NEJMoa1311376. N Engl J Med. 2014. PMID: 24963566 Clinical Trial.
BACKGROUND: Atrial fibrillation is a leading preventable cause of recurrent stroke for which early detection and treatment are critical. ...METHODS: We randomly assigned 572 patients 55 years of age or older, without known atrial fibrillation, who had had a cryptoge …
BACKGROUND: Atrial fibrillation is a leading preventable cause of recurrent stroke for which early detection and treatment are critic …
Age, risk-benefit trade-offs, and the projected effects of evidence-based therapies.
Alter DA, Manuel DG, Gunraj N, Anderson G, Naylor CD, Laupacis A. Alter DA, et al. Am J Med. 2004 Apr 15;116(8):540-5. doi: 10.1016/j.amjmed.2003.10.039. Am J Med. 2004. PMID: 15063816
We calculated the relative efficacy (relative risk reduction) needed to achieve a clinically meaningful absolute survival benefit, using a number needed to treat of 50 patients for the different age strata. ...Given this gradient, a therapy would have to have …
We calculated the relative efficacy (relative risk reduction) needed to achieve a clinically meaningful absolute survival benefit, us …
Impracticability of informed consent in the Registry of the Canadian Stroke Network.
Tu JV, Willison DJ, Silver FL, Fang J, Richards JA, Laupacis A, Kapral MK; Investigators in the Registry of the Canadian Stroke Network. Tu JV, et al. N Engl J Med. 2004 Apr 1;350(14):1414-21. doi: 10.1056/NEJMsa031697. N Engl J Med. 2004. PMID: 15070791
However, the effect of such a requirement on the use of clinical registries and the extent to which registry data can be generalized remain uncertain. METHODS: We examined the effectiveness of a comprehensive attempt to obtain informed consent between June 2001 and …
However, the effect of such a requirement on the use of clinical registries and the extent to which registry data can be generalized …
Erythropoietin to minimize perioperative blood transfusion: a systematic review of randomized trials. The International Study of Peri-operative Transfusion (ISPOT) Investigators.
Laupacis A, Fergusson D. Laupacis A, et al. Transfus Med. 1998 Dec;8(4):309-17. doi: 10.1046/j.1365-3148.1998.00171.x. Transfus Med. 1998. PMID: 9881425
A number of studies have been done to determine whether erythropoietin minimizes exposure to perioperative allogeneic red cell transfusion. A systematic review of all randomized trials will provide the best estimate of the efficacy and side-effects of erythropoietin
A number of studies have been done to determine whether erythropoietin minimizes exposure to perioperative allogeneic red cell transf
A comparison of aspirin with placebo in patients treated with warfarin after heart-valve replacement.
Turpie AG, Gent M, Laupacis A, Latour Y, Gunstensen J, Basile F, Klimek M, Hirsh J. Turpie AG, et al. N Engl J Med. 1993 Aug 19;329(8):524-9. doi: 10.1056/NEJM199308193290802. N Engl J Med. 1993. PMID: 8336751 Clinical Trial.
METHODS: In a randomized, double-blind, placebo-controlled trial, we assessed the efficacy and safety of adding aspirin (100 mg per day) to warfarin treatment (target international normalized ratio, 3.0 to 4.5) in 370 patients with mechanical heart valves or with tissue va …
METHODS: In a randomized, double-blind, placebo-controlled trial, we assessed the efficacy and safety of adding aspirin (100 mg per d …
A technology assessment study design.
Laupacis A, Bourne R, Rorabeck C, Leslie K. Laupacis A, et al. Dimens Health Serv. 1989 Oct;66(7):22-5, 35. Dimens Health Serv. 1989. PMID: 2612755
The area of competing technologies requires more research, and cemented and noncemented hip prostheses have recently been identified as an important example of such a technology. Although trials such as ours require considerable care in their planning and execution, they c …
The area of competing technologies requires more research, and cemented and noncemented hip prostheses have recently been identified as an i …
A patient decision aid regarding antithrombotic therapy for stroke prevention in atrial fibrillation: a randomized controlled trial.
Man-Son-Hing M, Laupacis A, O'Connor AM, Biggs J, Drake E, Yetisir E, Hart RG. Man-Son-Hing M, et al. JAMA. 1999 Aug 25;282(8):737-43. doi: 10.1001/jama.282.8.737. JAMA. 1999. PMID: 10463708 Clinical Trial.
PARTICIPANTS: A total of 287 patients from the SPAF III aspirin cohort study, in which patients with atrial fibrillation and a relatively low risk of stroke received 325 mg/d of aspirin and were followed up for a mean of 2 years. ...RESULTS: More patients in …
PARTICIPANTS: A total of 287 patients from the SPAF III aspirin cohort study, in which patients with atrial fibrillation and a
Decision aids for patients considering options affecting cancer outcomes: evidence of efficacy and policy implications.
O'Connor AM, Fiset V, DeGrasse C, Graham ID, Evans W, Stacey D, Laupacis A, Tugwell P. O'Connor AM, et al. J Natl Cancer Inst Monogr. 1999;(25):67-80. doi: 10.1093/oxfordjournals.jncimonographs.a024212. J Natl Cancer Inst Monogr. 1999. PMID: 10854460 Review.
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