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Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications.
Feinberg WM, Blackshear JL, Laupacis A, Kronmal R, Hart RG. Feinberg WM, et al. Among authors: laupacis a. Arch Intern Med. 1995 Mar 13;155(5):469-73. Arch Intern Med. 1995. PMID: 7864703
There are an estimated 2.2 million people in the United States with AF, with a median age of about 75 years. The prevalence of AF is 2.3% in people older than 40 years and 5.9% in those older than 65 years. ...In contrast to people with AF in the general population, patien …
There are an estimated 2.2 million people in the United States with AF, with a median age of about 75 years. The prevalence of AF is …
Use of statins and the subsequent development of deep vein thrombosis.
Ray JG, Mamdani M, Tsuyuki RT, Anderson DR, Yeo EL, Laupacis A. Ray JG, et al. Among authors: laupacis a. Arch Intern Med. 2001 Jun 11;161(11):1405-10. doi: 10.1001/archinte.161.11.1405. Arch Intern Med. 2001. PMID: 11386889
A second cohort of women only was evaluated in a similar fashion, but estrogen use was added as a third comparison drug group. ...A randomized clinical trial is needed to evaluate the efficacy of statins for the primary and secondary prevention of DVT.
A second cohort of women only was evaluated in a similar fashion, but estrogen use was added as a third comparison drug
Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysis.
van Walraven C, Hart RG, Singer DE, Laupacis A, Connolly S, Petersen P, Koudstaal PJ, Chang Y, Hellemons B. van Walraven C, et al. Among authors: laupacis a. JAMA. 2002 Nov 20;288(19):2441-8. doi: 10.1001/jama.288.19.2441. JAMA. 2002. PMID: 12435257
PATIENTS: A total of 4052 patients with AF randomly assigned to receive therapeutic doses of oral anticoagulant or aspirin with or without low-dose oral anticoagulants. ...
PATIENTS: A total of 4052 patients with AF randomly assigned to receive therapeutic doses of oral anticoagulant or aspirin with or wi …
Balancing the risks of stroke and upper gastrointestinal tract bleeding in older patients with atrial fibrillation.
Man-Son-Hing M, Laupacis A. Man-Son-Hing M, et al. Among authors: laupacis a. Arch Intern Med. 2002 Mar 11;162(5):541-50. doi: 10.1001/archinte.162.5.541. Arch Intern Med. 2002. PMID: 11871922
For persons with significantly higher risks of upper GI tract bleeding and/or lower risks of stroke, warfarin was no longer clearly the optimal antithrombotic therapy (eg, for 80-year-old persons with a baseline risk of stroke of 4.3% per year who were concurrently taking …
For persons with significantly higher risks of upper GI tract bleeding and/or lower risks of stroke, warfarin was no longer clearly the opti …
Preference-based antithrombotic therapy in atrial fibrillation: implications for clinical decision making.
Man-Son-Hing M, Gage BF, Montgomery AA, Howitt A, Thomson R, Devereaux PJ, Protheroe J, Fahey T, Armstrong D, Laupacis A. Man-Son-Hing M, et al. Among authors: laupacis a. Med Decis Making. 2005 Sep-Oct;25(5):548-59. doi: 10.1177/0272989X05280558. Med Decis Making. 2005. PMID: 16160210
In general, at a stroke rate of 1% with aspirin, half of the participants would prefer warfarin, and at a rate of 2% with aspirin, two thirds would prefer warfarin. In 3 studies, warfarin must provide at least a 0.9% to 3.0% per year absolute reduction in str …
In general, at a stroke rate of 1% with aspirin, half of the participants would prefer warfarin, and at a rate of 2% with aspi …
Anticoagulant-related bleeding in older persons with atrial fibrillation: physicians' fears often unfounded.
Man-Son-Hing M, Laupacis A. Man-Son-Hing M, et al. Among authors: laupacis a. Arch Intern Med. 2003 Jul 14;163(13):1580-6. doi: 10.1001/archinte.163.13.1580. Arch Intern Med. 2003. PMID: 12860581
For some other factors, such as alcoholism, participation in activities that predispose to trauma, the presence of a bleeding diathesis or thrombocytopenia, and noncompliance with monitoring, there is little or conflicting evidence about their effect on anticoagulant-relat …
For some other factors, such as alcoholism, participation in activities that predispose to trauma, the presence of a bleeding diathes …
A clinical prediction rule to identify patients with atrial fibrillation and a low risk for stroke while taking aspirin.
van Walraven C, Hart RG, Wells GA, Petersen P, Koudstaal PJ, Gullov AL, Hellemons BS, Koefed BG, Laupacis A. van Walraven C, et al. Among authors: laupacis a. Arch Intern Med. 2003 Apr 28;163(8):936-43. doi: 10.1001/archinte.163.8.936. Arch Intern Med. 2003. PMID: 12719203 Clinical Trial.
BACKGROUND: We sought to derive and internally validate a simple and easily applied clinical prediction rule to identify patients with nonvalvular atrial fibrillation (AF) whose stroke risk while taking aspirin is, irrespective of age, low enough that oral anticoagulation …
BACKGROUND: We sought to derive and internally validate a simple and easily applied clinical prediction rule to identify patients wit …
The Influence of Socioeconomic Status on Selection of Anticoagulation for Atrial Fibrillation.
Sholzberg M, Gomes T, Juurlink DN, Yao Z, Mamdani MM, Laupacis A. Sholzberg M, et al. Among authors: laupacis a. PLoS One. 2016 Feb 25;11(2):e0149142. doi: 10.1371/journal.pone.0149142. eCollection 2016. PLoS One. 2016. PMID: 26914450 Free PMC article.
Atrial fibrillation in patients with cryptogenic stroke.
Gladstone DJ, Spring M, Dorian P, Panzov V, Thorpe KE, Hall J, Vaid H, O'Donnell M, Laupacis A, Côté R, Sharma M, Blakely JA, Shuaib A, Hachinski V, Coutts SB, Sahlas DJ, Teal P, Yip S, Spence JD, Buck B, Verreault S, Casaubon LK, Penn A, Selchen D, Jin A, Howse D, Mehdiratta M, Boyle K, Aviv R, Kapral MK, Mamdani M; EMBRACE Investigators and Coordinators. Gladstone DJ, et al. Among authors: laupacis a. N Engl J Med. 2014 Jun 26;370(26):2467-77. doi: 10.1056/NEJMoa1311376. N Engl J Med. 2014. PMID: 24963566 Clinical Trial.
BACKGROUND: Atrial fibrillation is a leading preventable cause of recurrent stroke for which early detection and treatment are critical. ...METHODS: We randomly assigned 572 patients 55 years of age or older, without known atrial fibrillation, who had had a cryptoge …
BACKGROUND: Atrial fibrillation is a leading preventable cause of recurrent stroke for which early detection and treatment are critic …
Comparison of the impact of the Atrial Fibrillation Follow-Up Investigation of Rhythm Management trial on prescribing patterns: a time-series analysis.
Choudhry NK, Zagorski B, Avorn J, Levin R, Sykora K, Laupacis A, Mamdani M. Choudhry NK, et al. Among authors: laupacis a. Ann Pharmacother. 2008 Nov;42(11):1563-72. doi: 10.1345/aph.1L211. Epub 2008 Sep 30. Ann Pharmacother. 2008. PMID: 18827174
METHODS: We conducted a time-series analysis of 3 population-based cohorts of patients with AF who were 66 years of age or older in Pennsylvania and Ontario. ...In contrast, AFFIRM publication was also associated with a small increase in the use of rate controlling …
METHODS: We conducted a time-series analysis of 3 population-based cohorts of patients with AF who were 66 years of age or older in P …
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