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Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials.
Drevs J, Zirrgiebel U, Schmidt-Gersbach CI, Mross K, Medinger M, Lee L, Pinheiro J, Wood J, Thomas AL, Unger C, Henry A, Steward WP, Laurent D, Lebwohl D, Dugan M, Marmé D. Drevs J, et al. Among authors: laurent d. Ann Oncol. 2005 Apr;16(4):558-65. doi: 10.1093/annonc/mdi118. Epub 2005 Feb 10. Ann Oncol. 2005. PMID: 15705616 Free article.
A phase IB, open-label dose-escalating study of the oral angiogenesis inhibitor PTK787/ZK 222584 (PTK/ZK), in combination with FOLFOX4 chemotherapy in patients with advanced colorectal cancer.
Thomas AL, Trarbach T, Bartel C, Laurent D, Henry A, Poethig M, Wang J, Masson E, Steward W, Vanhoefer U, Wiedenmann B. Thomas AL, et al. Among authors: laurent d. Ann Oncol. 2007 Apr;18(4):782-8. doi: 10.1093/annonc/mdl469. Epub 2007 Jan 11. Ann Oncol. 2007. PMID: 17218488 Free article. Clinical Trial.
Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies.
Morgan B, Thomas AL, Drevs J, Hennig J, Buchert M, Jivan A, Horsfield MA, Mross K, Ball HA, Lee L, Mietlowski W, Fuxuis S, Unger C, O'Byrne K, Henry A, Cherryman GR, Laurent D, Dugan M, Marmé D, Steward WP. Morgan B, et al. Among authors: laurent d. J Clin Oncol. 2003 Nov 1;21(21):3955-64. doi: 10.1200/JCO.2003.08.092. Epub 2003 Sep 29. J Clin Oncol. 2003. PMID: 14517187 Clinical Trial.
PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor of vascular endothelial growth factor (VEGF), has modest activity in myelofibrosis with myeloid metaplasia.
Giles FJ, List AF, Carroll M, Cortes JE, Valickas J, Chen BL, Masson E, Jacques C, Laurent D, Albitar M, Feldman EJ, Roboz GJ. Giles FJ, et al. Among authors: laurent d. Leuk Res. 2007 Jul;31(7):891-7. doi: 10.1016/j.leukres.2006.12.001. Leuk Res. 2007. PMID: 17560285 Clinical Trial.
448 results