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Autoantibodies against recombinant human steroidogenic enzymes 21-hydroxylase, side-chain cleavage and 17alpha-hydroxylase in Addison's disease and autoimmune polyendocrine syndrome type III.
de Carmo Silva R, Kater CE, Dib SA, Laureti S, Forini F, Cosentino A, Falorni A. de Carmo Silva R, et al. Among authors: Laureti S. Eur J Endocrinol. 2000 Feb;142(2):187-94. doi: 10.1530/eje.0.1420187. Eur J Endocrinol. 2000. PMID: 10664529
OBJECTIVE: To evaluate the frequency of autoantibodies (Ab) against 21 hydroxylase (21OH), side-chain cleavage (SCC) and 17alpha-hydroxylase (17OH), in Addison's disease (AD) and autoimmune polyendocrine syndrome type III (APSIII). DESIGN AND METHODS: We used radiobinding …
OBJECTIVE: To evaluate the frequency of autoantibodies (Ab) against 21 hydroxylase (21OH), side-chain cleavage (SCC) and 17alpha-hydroxylase …
Elevated serum interferon-gamma-inducible chemokine-10/CXC chemokine ligand-10 in autoimmune primary adrenal insufficiency and in vitro expression in human adrenal cells primary cultures after stimulation with proinflammatory cytokines.
Rotondi M, Falorni A, De Bellis A, Laureti S, Ferruzzi P, Romagnani P, Buonamano A, Lazzeri E, Crescioli C, Mannelli M, Santeusanio F, Bellastella A, Serio M. Rotondi M, et al. Among authors: Laureti S. J Clin Endocrinol Metab. 2005 Apr;90(4):2357-63. doi: 10.1210/jc.2004-1062. Epub 2005 Jan 18. J Clin Endocrinol Metab. 2005. PMID: 15657375
Among CXC chemokines, CXC chemokine ligand 10 (CXCL10) has been identified to play an important role in several endocrinological autoimmune diseases, such as Hashimoto's thyroiditis, Graves' disease, and type 1 diabetes mellitus. ...The aim of this study was to evaluate th …
Among CXC chemokines, CXC chemokine ligand 10 (CXCL10) has been identified to play an important role in several endocrinological autoimmune …
Italian addison network study: update of diagnostic criteria for the etiological classification of primary adrenal insufficiency.
Falorni A, Laureti S, De Bellis A, Zanchetta R, Tiberti C, Arnaldi G, Bini V, Beck-Peccoz P, Bizzarro A, Dotta F, Mantero F, Bellastella A, Betterle C, Santeusanio F; SIE Addison Study Group. Falorni A, et al. Among authors: Laureti S. J Clin Endocrinol Metab. 2004 Apr;89(4):1598-604. doi: 10.1210/jc.2003-030954. J Clin Endocrinol Metab. 2004. PMID: 15070918 Clinical Trial.
In 145 subjects (65%), the presence of adrenal autoantibodies, without signs of other forms of PAI, led to a diagnosis of autoimmune Addison's disease. ...We conclude that the simultaneous presence of both 21OHAb and ACA permits unambiguous diagnosis of autoimmune Addison' …
In 145 subjects (65%), the presence of adrenal autoantibodies, without signs of other forms of PAI, led to a diagnosis of autoimmune Addison …
Dehydroepiandrosterone, 17alpha-hydroxyprogesterone and aldosterone responses to the low-dose (1 micro g) ACTH test in subjects with preclinical adrenal autoimmunity.
Laureti S, Candeloro P, Aglietti MC, Giordano R, Arvat E, Ghigo E, Santeusanio F, Falorni A. Laureti S, et al. Clin Endocrinol (Oxf). 2002 Nov;57(5):677-83. doi: 10.1046/j.1365-2265.2002.01651.x. Clin Endocrinol (Oxf). 2002. PMID: 12390344
Autoantibodies in autoimmune polyendocrine syndrome type II.
Falorni A, Laureti S, Santeusanio F. Falorni A, et al. Among authors: Laureti S. Endocrinol Metab Clin North Am. 2002 Jun;31(2):369-89, vii. doi: 10.1016/s0889-8529(01)00010-x. Endocrinol Metab Clin North Am. 2002. PMID: 12092456 Review.
The autoimmune polyendocrine syndrome type II (APS-II) is characterized by the association of autoimmune Addison's disease with thyroid autoimmune diseases or type-1 diabetes mellitus. 21-Hydroxylase autoantibodies enable the accurate diagnosis of autoimmune Addison's
The autoimmune polyendocrine syndrome type II (APS-II) is characterized by the association of autoimmune Addison's disease with thyro …
Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity.
Falorni A, Laureti S, Candeloro P, Perrino S, Coronella C, Bizzarro A, Bellastella A, Santeusanio F, De Bellis A. Falorni A, et al. Among authors: Laureti S. Fertil Steril. 2002 Aug;78(2):270-9. doi: 10.1016/s0015-0282(02)03205-3. Fertil Steril. 2002. PMID: 12137862
MAIN OUTCOME MEASURE(S): Serum levels of steroid-cell autoantibodies, 17alpha-OH antibodies, P450 side-chain cleavage antibodies, and 3beta-HSD antibodies. ...CONCLUSION(S): Markers of steroid-cell autoimmunity are found only rarely in idiopathic premature ovarian f …
MAIN OUTCOME MEASURE(S): Serum levels of steroid-cell autoantibodies, 17alpha-OH antibodies, P450 side-chain cleavage antibodies, and …
Low dose (1 microg) ACTH test in the evaluation of adrenal dysfunction in pre-clinical Addison's disease.
Laureti S, Arvat E, Candeloro P, Di Vito L, Ghigo E, Santeusanio F, Falorni A. Laureti S, et al. Clin Endocrinol (Oxf). 2000 Jul;53(1):107-15. doi: 10.1046/j.1365-2265.2000.01050.x. Clin Endocrinol (Oxf). 2000. PMID: 10931087 Clinical Trial.
OBJECTIVE: The presence of 21-hydroxylase autoantibodies (21OHAb) is a marker of adrenal autoimmunity and can be used to identify subjects with pre-clinical Addison's disease. ...We then performed a LDT in 11 subjects positive for 21OHAb, but without clinical signs of Addi …
OBJECTIVE: The presence of 21-hydroxylase autoantibodies (21OHAb) is a marker of adrenal autoimmunity and can be used to identify subjects w …
A conformation-dependent epitope in Addison's disease and other endocrinological autoimmune diseases maps to a carboxyl-terminal functional domain of human steroid 21-hydroxylase.
Nikoshkov A, Falorni A, Lajic S, Laureti S, Wedell A, Lernmark K, Luthman H. Nikoshkov A, et al. Among authors: Laureti S. J Immunol. 1999 Feb 15;162(4):2422-6. J Immunol. 1999. PMID: 9973524
Idiopathic Addison's disease develops as a consequence of autoimmune destruction of steroid-producing cells in the adrenal gland. ...Sera from 21OHAb-positive patients with idiopathic Addison's disease (n = 24), Graves' disease (n = 3), and insulin-dependent diabete …
Idiopathic Addison's disease develops as a consequence of autoimmune destruction of steroid-producing cells in the adrenal gland. ... …
Detection of adrenocortical autoantibodies in Addison's disease with a peroxidase-labelled protein A technique.
Silva RC, Faiçal S, Laureti S, Falorni A, Dib SA, Kater CE. Silva RC, et al. Among authors: Laureti S. Braz J Med Biol Res. 1998 Sep;31(9):1141-8. doi: 10.1590/s0100-879x1998000900007. Braz J Med Biol Res. 1998. PMID: 9876281
Adrenocortical autoantibodies (ACA), present in 60-80% of patients with idiopathic Addison's disease, are conventionally detected by indirect immunofluorescence (IIF) on frozen sections of adrenal glands. ...We studied serum samples from 90 healthy control subjects and 22 …
Adrenocortical autoantibodies (ACA), present in 60-80% of patients with idiopathic Addison's disease, are conventionally detected by …
Levels of adrenocortical autoantibodies correlate with the degree of adrenal dysfunction in subjects with preclinical Addison's disease.
Laureti S, De Bellis A, Muccitelli VI, Calcinaro F, Bizzarro A, Rossi R, Bellastella A, Santeusanio F, Falorni A. Laureti S, et al. J Clin Endocrinol Metab. 1998 Oct;83(10):3507-11. doi: 10.1210/jcem.83.10.5149. J Clin Endocrinol Metab. 1998. PMID: 9768655
To test the hypothesis that levels of adrenal autoantibodies correlate with the degree of adrenal dysfunction, we followed up adrenal cortex autoantibody (ACA) titers and 21-hydroxylase (21OH) autoantibody (21OHAb) levels in 19 ACA-positive subjects with preclinical Addison's
To test the hypothesis that levels of adrenal autoantibodies correlate with the degree of adrenal dysfunction, we followed up adrenal cortex …
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