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Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction.
Sparsø T, Grarup N, Andreasen C, Albrechtsen A, Holmkvist J, Andersen G, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O. Sparsø T, et al. Among authors: lauritzen t. Diabetologia. 2009 Jul;52(7):1308-14. doi: 10.1007/s00125-009-1362-3. Epub 2009 Apr 29. Diabetologia. 2009. PMID: 19404609
Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.
Grarup N, Rose CS, Andersson EA, Andersen G, Nielsen AL, Albrechtsen A, Clausen JO, Rasmussen SS, Jørgensen T, Sandbaek A, Lauritzen T, Schmitz O, Hansen T, Pedersen O. Grarup N, et al. Among authors: lauritzen t. Diabetes. 2007 Dec;56(12):3105-11. doi: 10.2337/db07-0856. Epub 2007 Sep 7. Diabetes. 2007. PMID: 17827400
Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects.
Grarup N, Stender-Petersen KL, Andersson EA, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Schmitz O, Hansen T, Pedersen O. Grarup N, et al. Among authors: lauritzen t. Diabetes. 2008 Apr;57(4):1136-42. doi: 10.2337/db07-1534. Epub 2008 Jan 11. Diabetes. 2008. PMID: 18192539
The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects.
Grarup N, Andreasen CH, Andersen MK, Albrechtsen A, Sandbaek A, Lauritzen T, Borch-Johnsen K, Jørgensen T, Schmitz O, Hansen T, Pedersen O. Grarup N, et al. Among authors: lauritzen t. J Clin Endocrinol Metab. 2008 Jun;93(6):2294-9. doi: 10.1210/jc.2007-2815. Epub 2008 Mar 25. J Clin Endocrinol Metab. 2008. PMID: 18364377
Effect of population screening for type 2 diabetes and cardiovascular risk factors on mortality rate and cardiovascular events: a controlled trial among 1,912,392 Danish adults.
Simmons RK, Griffin SJ, Witte DR, Borch-Johnsen K, Lauritzen T, Sandbæk A. Simmons RK, et al. Among authors: lauritzen t. Diabetologia. 2017 Nov;60(11):2183-2191. doi: 10.1007/s00125-017-4323-2. Epub 2017 Aug 23. Diabetologia. 2017. PMID: 28831535 Free PMC article. Clinical Trial.
The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.
Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, Nielsen AL, Albrechtsen A, Rasmussen SS, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O. Sparsø T, et al. Among authors: lauritzen t. Diabetologia. 2008 Jan;51(1):70-5. doi: 10.1007/s00125-007-0865-z. Epub 2007 Nov 16. Diabetologia. 2008. PMID: 18008060
352 results