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A novel double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]tofogliflozin after oral administration and concomitant intravenous microdose administration of [13C]tofogliflozin in humans.
Schwab D, Portron A, Backholer Z, Lausecker B, Kawashima K. Schwab D, et al. Among authors: lausecker b. Clin Pharmacokinet. 2013 Jun;52(6):463-73. doi: 10.1007/s40262-013-0051-z. Clin Pharmacokinet. 2013. PMID: 23494983 Clinical Trial.
Reduced exposure variability of the CYP3A substrate simvastatin by dose individualization to CYP3A activity.
Stoll F, Burhenne J, Lausecker B, Weiss J, Thomsen T, Haefeli WE, Mikus G. Stoll F, et al. Among authors: lausecker b. J Clin Pharmacol. 2013 Nov;53(11):1199-204. doi: 10.1002/jcph.161. Epub 2013 Aug 31. J Clin Pharmacol. 2013. PMID: 23939663 Clinical Trial.
Metabolic profiles of minimally absorbed orlistat in obese/overweight volunteers.
Zhi J, Melia AT, Funk C, Viger-Chougnet A, Hopfgartner G, Lausecker B, Wang K, Fulton JS, Gabriel L, Mulligan TE. Zhi J, et al. J Clin Pharmacol. 1996 Nov;36(11):1006-11. doi: 10.1177/009127009603601104. J Clin Pharmacol. 1996. PMID: 8973989 Clinical Trial.
Pharmacokinetics and pharmacodynamics of sibrafiban alone or in combination with ticlopidine and aspirin.
Wittke B, Ensor H, Chung J, Birnböck H, Lausecker B, Ertel SI, MacKie IJ, Machin SJ. Wittke B, et al. Br J Clin Pharmacol. 2000 Mar;49(3):231-9. doi: 10.1046/j.1365-2125.2000.049003231.x. Br J Clin Pharmacol. 2000. PMID: 10718778 Free PMC article. Clinical Trial.
Determination of the enantiomeric composition of a new insulin sensitizer in plasma samples from non-clinical and clinical investigations using chiral HPLC with electrospray tandem mass spectrometric detection.
Lausecker B, Fischer G. Lausecker B, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 1;835(1-2):40-6. doi: 10.1016/j.jchromb.2006.03.003. Epub 2006 Mar 29. J Chromatogr B Analyt Technol Biomed Life Sci. 2006. PMID: 16567137
Simultaneous determination of bosentan and its three major metabolites in various biological matrices and species using narrow bore liquid chromatography with ion spray tandem mass spectrometric detection.
Lausecker B, Hess B, Fischer G, Mueller M, Hopfgartner G. Lausecker B, et al. J Chromatogr B Biomed Sci Appl. 2000 Nov 10;749(1):67-83. doi: 10.1016/s0378-4347(00)00386-8. J Chromatogr B Biomed Sci Appl. 2000. PMID: 11129080
Micro liquid chromatography-mass spectrometry with direct liquid introduction used for separation and quantitation of all-trans- and 13-cis-retinoic acids and their 4-oxo metabolites in human plasma.
Ranalder UB, Lausecker BB, Huselton C. Ranalder UB, et al. J Chromatogr. 1993 Jul 23;617(1):129-35. doi: 10.1016/0378-4347(93)80431-3. J Chromatogr. 1993. PMID: 8376526
Co-medication and interference testing in bioanalysis: a European Bioanalysis Forum recommendation.
de Zwart M, Lausecker B, Globig S, Neddermann D, Le Bras B, Guenzi A, White S, Scheel-Fjording M, Timmerman P. de Zwart M, et al. Among authors: lausecker b. Bioanalysis. 2016 Oct;8(19):2065-70. doi: 10.4155/bio-2016-0179. Epub 2016 Jul 15. Bioanalysis. 2016. PMID: 27416776 Free article.
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