Lavé T - Search Results

1

Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity.

Groebke Zbinden K, Banner DW, Hilpert K, Himber J, Lavé T, Riederer MA, Stahl M, Tschopp TB, Obst-Sander U. Groebke Zbinden K, et al. Among authors: lave t. Bioorg Med Chem. 2006 Aug 1;14(15):5357-69. doi: 10.1016/j.bmc.2006.03.042. Epub 2006 Apr 18. Bioorg Med Chem. 2006. PMID: 16621574

2

Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.

Zbinden KG, Obst-Sander U, Hilpert K, Kühne H, Banner DW, Böhm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lavé T. Zbinden KG, et al. Among authors: lave t. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. doi: 10.1016/j.bmcl.2005.04.079. Epub 2005 Oct 4. Bioorg Med Chem Lett. 2005. PMID: 16213138

3

Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques.

Schneider G, Coassolo P, Lavé T. Schneider G, et al. Among authors: lave t. J Med Chem. 1999 Dec 16;42(25):5072-6. doi: 10.1021/jm991030j. J Med Chem. 1999. PMID: 10602692

4

Piperidine renin inhibitors: from leads to drug candidates.

Märki HP, Binggeli A, Bittner B, Bohner-Lang V, Breu V, Bur D, Coassolo PH, Clozel JP, D'Arcy A, Doebeli H, Fischli W, Funk CH, Foricher J, Giller T, Grüninger F, Guenzi A, Güller R, Hartung T, Hirth G, Jenny CH, Kansy M, Klinkhammer U, Lave T, Lohri B, Luft FC, Mervaala EM, Müller DN, Müller M, Montavon F, Oefner CH, Qiu C, Reichel A, Sanwald-Ducray P, Scalone M, Schleimer M, Schmid R, Stadler H, Treiber A, Valdenaire O, Vieira E, Waldmeier P, Wiegand-Chou R, Wilhelm M, Wostl W, Zell M, Zell R. Märki HP, et al. Among authors: lave t. Farmaco. 2001 Jan-Feb;56(1-2):21-7. doi: 10.1016/s0014-827x(01)01004-7. Farmaco. 2001. PMID: 11347960

5

Development of a physiologically based model for oseltamivir and simulation of pharmacokinetics in neonates and infants.

Parrott N, Davies B, Hoffmann G, Koerner A, Lave T, Prinssen E, Theogaraj E, Singer T. Parrott N, et al. Among authors: lave t. Clin Pharmacokinet. 2011 Sep;50(9):613-23. doi: 10.2165/11592640-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21827216

6

A pharmacokinetic-pharmacodynamic model for cardiovascular safety assessment of R1551.

Fleury A, Lavé T, Jonsson F, Schmitt M, Hirkaler G, Polonchuk L, Breidenbach A. Fleury A, et al. Among authors: lave t. J Pharmacol Toxicol Methods. 2011 Jan-Feb;63(1):123-33. doi: 10.1016/j.vascn.2010.08.003. Epub 2010 Aug 21. J Pharmacol Toxicol Methods. 2011. PMID: 20732434

7

Challenges and opportunities with modelling and simulation in drug discovery and drug development.

Lavé T, Parrott N, Grimm HP, Fleury A, Reddy M. Lavé T, et al. Xenobiotica. 2007 Oct-Nov;37(10-11):1295-310. doi: 10.1080/00498250701534885. Xenobiotica. 2007. PMID: 17968746

8

Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man.

Parrott N, Jones H, Paquereau N, Lavé T. Parrott N, et al. Among authors: lave t. Basic Clin Pharmacol Toxicol. 2005 Mar;96(3):193-9. doi: 10.1111/j.1742-7843.2005.pto960308.x. Basic Clin Pharmacol Toxicol. 2005. PMID: 15733214 Free article.

9

A novel strategy for physiologically based predictions of human pharmacokinetics.

Jones HM, Parrott N, Jorga K, Lavé T. Jones HM, et al. Among authors: lave t. Clin Pharmacokinet. 2006;45(5):511-42. doi: 10.2165/00003088-200645050-00006. Clin Pharmacokinet. 2006. PMID: 16640456

10

Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development.

Caruso A, Frances N, Meille C, Greiter-Wilke A, Hillebrecht A, Lavé T. Caruso A, et al. Among authors: lave t. J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):73-85. doi: 10.1016/j.vascn.2014.05.004. Epub 2014 May 28. J Pharmacol Toxicol Methods. 2014. PMID: 24879942

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