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5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.
Petrelli R, Torquati I, Kachler S, Luongo L, Maione S, Franchetti P, Grifantini M, Novellino E, Lavecchia A, Klotz KN, Cappellacci L. Petrelli R, et al. J Med Chem. 2015 Mar 12;58(5):2560-6. doi: 10.1021/acs.jmedchem.5b00074. Epub 2015 Feb 27. J Med Chem. 2015. PMID: 25699637
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.
La Regina G, Edler MC, Brancale A, Kandil S, Coluccia A, Piscitelli F, Hamel E, De Martino G, Matesanz R, Díaz JF, Scovassi AI, Prosperi E, Lavecchia A, Novellino E, Artico M, Silvestri R. La Regina G, et al. J Med Chem. 2007 Jun 14;50(12):2865-74. doi: 10.1021/jm061479u. Epub 2007 May 12. J Med Chem. 2007. PMID: 17497841
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity.
Piemontese L, Cerchia C, Laghezza A, Ziccardi P, Sblano S, Tortorella P, Iacobazzi V, Infantino V, Convertini P, Dal Piaz F, Lupo A, Colantuoni V, Lavecchia A, Loiodice F. Piemontese L, et al. Eur J Med Chem. 2017 Feb 15;127:379-397. doi: 10.1016/j.ejmech.2016.12.047. Epub 2016 Dec 24. Eur J Med Chem. 2017. PMID: 28076827
Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A1 Adenosine Receptor Agonists.
Petrelli R, Scortichini M, Belardo C, Boccella S, Luongo L, Capone F, Kachler S, Vita P, Del Bello F, Maione S, Lavecchia A, Klotz KN, Cappellacci L. Petrelli R, et al. J Med Chem. 2018 Jan 11;61(1):305-318. doi: 10.1021/acs.jmedchem.7b01399. Epub 2018 Jan 3. J Med Chem. 2018. PMID: 29257884
Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ∇.
Petrelli R, Scortichini M, Kachler S, Boccella S, Cerchia C, Torquati I, Del Bello F, Salvemini D, Novellino E, Luongo L, Maione S, Jacobson KA, Lavecchia A, Klotz KN, Cappellacci L. Petrelli R, et al. J Med Chem. 2017 May 25;60(10):4327-4341. doi: 10.1021/acs.jmedchem.7b00291. Epub 2017 May 5. J Med Chem. 2017. PMID: 28447789 Free PMC article.
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