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The identification of plant lectins with mucosal adjuvant activity.
Lavelle EC, Grant G, Pusztai A, Pfüller U, O'Hagan DT. Lavelle EC, et al. Immunology. 2001 Jan;102(1):77-86. doi: 10.1046/j.1365-2567.2001.01157.x. Immunology. 2001. PMID: 11168640 Free PMC article.
Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2.
Lavelle EC, Grant G, Pusztai A, Pfüller U, Leavy O, McNeela E, Mills KH, O'Hagan DT. Lavelle EC, et al. Immunology. 2002 Oct;107(2):268-74. doi: 10.1046/j.1365-2567.2002.01492.x. Immunology. 2002. PMID: 12383207 Free PMC article.
Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology.
Higgins SC, Lavelle EC, McCann C, Keogh B, McNeela E, Byrne P, O'Gorman B, Jarnicki A, McGuirk P, Mills KH. Higgins SC, et al. J Immunol. 2003 Sep 15;171(6):3119-27. doi: 10.4049/jimmunol.171.6.3119. J Immunol. 2003. PMID: 12960338
Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent.
Lavelle EC, Jarnicki A, McNeela E, Armstrong ME, Higgins SC, Leavy O, Mills KH. Lavelle EC, et al. J Leukoc Biol. 2004 May;75(5):756-63. doi: 10.1189/jlb.1103534. Epub 2004 Jan 2. J Leukoc Biol. 2004. PMID: 14704372 Review.
Molecules of infectious agents as immunomodulatory drugs.
Lavelle EC, McGuirk P, Mills KH. Lavelle EC, et al. Curr Top Med Chem. 2004;4(5):499-508. doi: 10.2174/1568026043451249. Curr Top Med Chem. 2004. PMID: 14965301 Review.
Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells.
Ross PJ, Lavelle EC, Mills KH, Boyd AP. Ross PJ, et al. Infect Immun. 2004 Mar;72(3):1568-79. doi: 10.1128/iai.72.3.1568-1579.2004. Infect Immun. 2004. PMID: 14977963 Free PMC article.
Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death.
Boyd AP, Ross PJ, Conroy H, Mahon N, Lavelle EC, Mills KH. Boyd AP, et al. J Immunol. 2005 Jul 15;175(2):730-8. doi: 10.4049/jimmunol.175.2.730. J Immunol. 2005. PMID: 16002668
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