Lawler J - Search Results

1

Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis.

Shaked Y, Bertolini F, Man S, Rogers MS, Cervi D, Foutz T, Rawn K, Voskas D, Dumont DJ, Ben-David Y, Lawler J, Henkin J, Huber J, Hicklin DJ, D'Amato RJ, Kerbel RS. Shaked Y, et al. Among authors: lawler j. Cancer Cell. 2005 Jan;7(1):101-11. doi: 10.1016/j.ccr.2004.11.023. Cancer Cell. 2005. PMID: 15652753 Free article.

2

Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy.

Bocci G, Francia G, Man S, Lawler J, Kerbel RS. Bocci G, et al. Among authors: lawler j. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12917-22. doi: 10.1073/pnas.2135406100. Epub 2003 Oct 15. Proc Natl Acad Sci U S A. 2003. PMID: 14561896 Free PMC article.

3

Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1.

Niu Q, Perruzzi C, Voskas D, Lawler J, Dumont DJ, Benjamin LE. Niu Q, et al. Among authors: lawler j. Cancer Biol Ther. 2004 Apr;3(4):402-5. doi: 10.4161/cbt.3.4.735. Epub 2004 Apr 29. Cancer Biol Ther. 2004. PMID: 14739779

4

ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer.

Greenaway J, Henkin J, Lawler J, Moorehead R, Petrik J. Greenaway J, et al. Among authors: lawler j. Mol Cancer Ther. 2009 Jan;8(1):64-74. doi: 10.1158/1535-7163.MCT-08-0864. Mol Cancer Ther. 2009. PMID: 19139114 Free PMC article.

5

Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1).

Greenaway J, Lawler J, Moorehead R, Bornstein P, Lamarre J, Petrik J. Greenaway J, et al. Among authors: lawler j. J Cell Physiol. 2007 Mar;210(3):807-18. doi: 10.1002/jcp.20904. J Cell Physiol. 2007. PMID: 17154366 Free PMC article.

6

Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression.

Hamano Y, Sugimoto H, Soubasakos MA, Kieran M, Olsen BR, Lawler J, Sudhakar A, Kalluri R. Hamano Y, et al. Among authors: lawler j. Cancer Res. 2004 Mar 1;64(5):1570-4. doi: 10.1158/0008-5472.can-03-3126. Cancer Res. 2004. PMID: 14996710

7

Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins.

Short SM, Derrien A, Narsimhan RP, Lawler J, Ingber DE, Zetter BR. Short SM, et al. Among authors: lawler j. J Cell Biol. 2005 Feb 14;168(4):643-53. doi: 10.1083/jcb.200407060. J Cell Biol. 2005. PMID: 15716381 Free PMC article.

8

A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR.

Ren B, Song K, Parangi S, Jin T, Ye M, Humphreys R, Duquette M, Zhang X, Benhaga N, Lawler J, Khosravi-Far R. Ren B, et al. Among authors: lawler j. Cancer Res. 2009 May 1;69(9):3856-65. doi: 10.1158/0008-5472.CAN-08-2940. Epub 2009 Apr 14. Cancer Res. 2009. PMID: 19366809 Free PMC article.

9

Combined therapy with thrombospondin-1 type I repeats (3TSR) and chemotherapy induces regression and significantly improves survival in a preclinical model of advanced stage epithelial ovarian cancer.

Russell S, Duquette M, Liu J, Drapkin R, Lawler J, Petrik J. Russell S, et al. Among authors: lawler j. FASEB J. 2015 Feb;29(2):576-88. doi: 10.1096/fj.14-261636. Epub 2014 Nov 13. FASEB J. 2015. PMID: 25395453 Free PMC article.

In this study, we describe a novel treatment approach and mechanism of action with 3TSR and chemotherapy that induces regression of advanced stage EOC and significantly improves survival.-Russell, S., Duquette, M., Liu, J., Drapkin, R., Lawler, J., Petrik, …

In this study, we describe a novel treatment approach and mechanism of action with 3TSR and chemotherapy that induces regression of advanced …

10

Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2.

Lawler PR, Lawler J. Lawler PR, et al. Among authors: lawler j. Cold Spring Harb Perspect Med. 2012 May;2(5):a006627. doi: 10.1101/cshperspect.a006627. Cold Spring Harb Perspect Med. 2012. PMID: 22553494 Free PMC article. Review.

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