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95 results
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Intrinsic disorder and protein function.
Dunker AK, Brown CJ, Lawson JD, Iakoucheva LM, Obradović Z. Dunker AK, et al. Among authors: lawson jd. Biochemistry. 2002 May 28;41(21):6573-82. doi: 10.1021/bi012159+. Biochemistry. 2002. PMID: 12022860 No abstract available.
Intrinsically disordered protein.
Dunker AK, Lawson JD, Brown CJ, Williams RM, Romero P, Oh JS, Oldfield CJ, Campen AM, Ratliff CM, Hipps KW, Ausio J, Nissen MS, Reeves R, Kang C, Kissinger CR, Bailey RW, Griswold MD, Chiu W, Garner EC, Obradovic Z. Dunker AK, et al. Among authors: lawson jd. J Mol Graph Model. 2001;19(1):26-59. doi: 10.1016/s1093-3263(00)00138-8. J Mol Graph Model. 2001. PMID: 11381529 Review.
Structural model of the regulatory domain of smooth muscle heavy meromyosin.
Wahlstrom JL, Randall MA Jr, Lawson JD, Lyons DE, Siems WF, Crouch GJ, Barr R, Facemyer KC, Cremo CR. Wahlstrom JL, et al. Among authors: lawson jd. J Biol Chem. 2003 Feb 14;278(7):5123-31. doi: 10.1074/jbc.M206963200. Epub 2002 Nov 21. J Biol Chem. 2003. PMID: 12446732
Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design.
Sabat M, Dougan DR, Knight B, Lawson JD, Scorah N, Smith CR, Taylor ER, Vu P, Wyrick C, Wang H, Balakrishna D, Hixon M, Madakamutil L, McConn D. Sabat M, et al. Among authors: lawson jd. J Med Chem. 2021 Sep 9;64(17):12893-12902. doi: 10.1021/acs.jmedchem.1c01026. Epub 2021 Aug 27. J Med Chem. 2021. PMID: 34448571
Acquired Resistance to KRASG12C Inhibition in Cancer.
Awad MM, Liu S, Rybkin II, Arbour KC, Dilly J, Zhu VW, Johnson ML, Heist RS, Patil T, Riely GJ, Jacobson JO, Yang X, Persky NS, Root DE, Lowder KE, Feng H, Zhang SS, Haigis KM, Hung YP, Sholl LM, Wolpin BM, Wiese J, Christiansen J, Lee J, Schrock AB, Lim LP, Garg K, Li M, Engstrom LD, Waters L, Lawson JD, Olson P, Lito P, Ou SI, Christensen JG, Jänne PA, Aguirre AJ. Awad MM, et al. Among authors: lawson jd. N Engl J Med. 2021 Jun 24;384(25):2382-2393. doi: 10.1056/NEJMoa2105281. N Engl J Med. 2021. PMID: 34161704
Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.
Fushimi M, Fujimori I, Wakabayashi T, Hasui T, Kawakita Y, Imamura K, Kato T, Murakami M, Ishii T, Kikko Y, Kasahara M, Nakatani A, Hiura Y, Miyamoto M, Saikatendu K, Zou H, Lane SW, Lawson JD, Imoto H. Fushimi M, et al. Among authors: lawson jd. J Med Chem. 2019 May 23;62(10):4915-4935. doi: 10.1021/acs.jmedchem.8b01630. Epub 2019 May 3. J Med Chem. 2019. PMID: 31009559
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