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Cellular signaling by fibroblast growth factor receptors.
Eswarakumar VP, Lax I, Schlessinger J. Eswarakumar VP, et al. Among authors: lax i. Cytokine Growth Factor Rev. 2005 Apr;16(2):139-49. doi: 10.1016/j.cytogfr.2005.01.001. Epub 2005 Feb 1. Cytokine Growth Factor Rev. 2005. PMID: 15863030 Review.
Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Lee S, Choi J, Mohanty J, Sousa LP, Tome F, Pardon E, Steyaert J, Lemmon MA, Lax I, Schlessinger J. Lee S, et al. Among authors: lax i. Nature. 2018 Jan 25;553(7689):501-505. doi: 10.1038/nature25010. Epub 2018 Jan 17. Nature. 2018. PMID: 29342135 Free PMC article.
Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, Bai H, Gunel M, Lax I, Schlessinger J. Reshetnyak AV, et al. Among authors: lax i. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15862-7. doi: 10.1073/pnas.1520099112. Epub 2015 Nov 16. Proc Natl Acad Sci U S A. 2015. PMID: 26630010 Free PMC article.
Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.
Lew ED, Oh J, Burrola PG, Lax I, Zagórska A, Través PG, Schlessinger J, Lemke G. Lew ED, et al. Among authors: lax i. Elife. 2014 Sep 29;3:e03385. doi: 10.7554/eLife.03385. Elife. 2014. PMID: 25265470 Free PMC article.
The docking protein FRS2α is a critical regulator of VEGF receptors signaling.
Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M. Chen PY, et al. Among authors: lax i. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5514-9. doi: 10.1073/pnas.1404545111. Epub 2014 Apr 2. Proc Natl Acad Sci U S A. 2014. PMID: 24706887 Free PMC article.
Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers.
Opatowsky Y, Lax I, Tomé F, Bleichert F, Unger VM, Schlessinger J. Opatowsky Y, et al. Among authors: lax i. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1772-7. doi: 10.1073/pnas.1323254111. Epub 2014 Jan 21. Proc Natl Acad Sci U S A. 2014. PMID: 24449920 Free PMC article.
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Reshetnyak AV, Nelson B, Shi X, Boggon TJ, Pavlenco A, Mandel-Bausch EM, Tome F, Suzuki Y, Sidhu SS, Lax I, Schlessinger J. Reshetnyak AV, et al. Among authors: lax i. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17832-7. doi: 10.1073/pnas.1317118110. Epub 2013 Oct 14. Proc Natl Acad Sci U S A. 2013. PMID: 24127596 Free PMC article.
Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.
Sousa LP, Lax I, Shen H, Ferguson SM, De Camilli P, Schlessinger J. Sousa LP, et al. Among authors: lax i. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4419-24. doi: 10.1073/pnas.1200164109. Epub 2012 Feb 27. Proc Natl Acad Sci U S A. 2012. PMID: 22371560 Free PMC article.
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Bae JH, Boggon TJ, Tomé F, Mandiyan V, Lax I, Schlessinger J. Bae JH, et al. Among authors: lax i. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2866-71. doi: 10.1073/pnas.0914157107. Epub 2010 Jan 26. Proc Natl Acad Sci U S A. 2010. PMID: 20133753 Free PMC article.
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Bae JH, Lew ED, Yuzawa S, Tomé F, Lax I, Schlessinger J. Bae JH, et al. Among authors: lax i. Cell. 2009 Aug 7;138(3):514-24. doi: 10.1016/j.cell.2009.05.028. Cell. 2009. PMID: 19665973 Free PMC article.
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