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Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans.
Layer P, Carlson GL, DiMagno EP. Layer P, et al. Gastroenterology. 1985 Jun;88(6):1895-902. doi: 10.1016/0016-5085(85)90016-2. Gastroenterology. 1985. PMID: 2581844
Compared with a commercial preparation and crude bean extract, this partially purified inhibitor inactivated intraduodenal, intraileal, and salivary amylase in vitro faster and more completely (p less than 0.001); its specific activity was not affected by exposure to gastr …
Compared with a commercial preparation and crude bean extract, this partially purified inhibitor inactivated intraduodenal, intraileal, and …
Altered postprandial motility in chronic pancreatitis: role of malabsorption.
Layer P, von der Ohe MR, Holst JJ, Jansen JB, Grandt D, Holtmann G, Goebell H. Layer P, et al. Gastroenterology. 1997 May;112(5):1624-34. doi: 10.1016/s0016-5085(97)70045-3. Gastroenterology. 1997. PMID: 9136842 Clinical Trial.
Effects of decreasing intraluminal amylase activity on starch digestion and postprandial gastrointestinal function in humans.
Layer P, Zinsmeister AR, DiMagno EP. Layer P, et al. Gastroenterology. 1986 Jul;91(1):41-8. doi: 10.1016/0016-5085(86)90436-1. Gastroenterology. 1986. PMID: 2423408 Clinical Trial.
Compared with placebo, the amylase inhibitor significantly (p less than 0.05) reduced duodenal, jejunal, and ileal intraluminal amylase activity by more than 95% for 1-2 h; increased postprandial delivery of total carbohydrate (glucose polymers in particular) to the distal …
Compared with placebo, the amylase inhibitor significantly (p less than 0.05) reduced duodenal, jejunal, and ileal intraluminal amyla …
Adrenergic modulation of interdigestive pancreatic secretion in humans.
Layer PH, Chan AT, Go VL, Zinsmeister AR, DiMagno EP. Layer PH, et al. Gastroenterology. 1992 Sep;103(3):990-3. doi: 10.1016/0016-5085(92)90033-u. Gastroenterology. 1992. PMID: 1499947 Clinical Trial.
Analysis of variance showed that epinephrine decreased trypsin output by 43% (P less than 0.05). By contrast, trypsin output was increased fourfold in the presence of phentolamine (P less than 0.01), whereas propranolol had no effect. ...
Analysis of variance showed that epinephrine decreased trypsin output by 43% (P less than 0.05). By contrast, trypsin output was incr …
Effects of acute hypercalcemia on exocrine pancreatic secretion in the cat.
Layer P, Hotz J, Eysselein VE, Jansen JB, Lamers CB, Schmitz-Moormann HP, Goebell H. Layer P, et al. Gastroenterology. 1985 May;88(5 Pt 1):1168-74. doi: 10.1016/s0016-5085(85)80076-7. Gastroenterology. 1985. PMID: 2579866
Increasing hypercalcemia (3.7-6.3 mmol/L) evoked a dose-dependent increase in enzyme output that was 12 times greater than in normocalcemic controls (p less than 0.001) and was 60% of subsequent maximal stimulation with intravenous cholecystokinin (CCK). ...Plasma levels o …
Increasing hypercalcemia (3.7-6.3 mmol/L) evoked a dose-dependent increase in enzyme output that was 12 times greater than in normocalcemic …
Bile-stimulated secretin release in cats.
Hanssen LE, Hotz J, Layer P, Goebell H. Hanssen LE, et al. Scand J Gastroenterol. 1986 Sep;21(7):886-90. doi: 10.3109/00365528609011134. Scand J Gastroenterol. 1986. PMID: 3775254
Dose-response studies with TC, pH 7.2 (0-60 mM, made isotonic with NaCl, 45 ml/h for 20 min), demonstrated a threshold concentration of TC for IRS release between 10 and 15 mM (p = 0.05; n = 6). ...IRS concentrations also increased when gallbladder bile was mixed with eith …
Dose-response studies with TC, pH 7.2 (0-60 mM, made isotonic with NaCl, 45 ml/h for 20 min), demonstrated a threshold concentration of TC f …
Delivery and fate of oral mesalamine microgranules within the human small intestine.
Layer PH, Goebell H, Keller J, Dignass A, Klotz U. Layer PH, et al. Gastroenterology. 1995 May;108(5):1427-33. doi: 10.1016/0016-5085(95)90691-6. Gastroenterology. 1995. PMID: 7729635
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