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A novel type of endotoxin structure present in Bordetella pertussis. Isolation of two different polysaccharides bound to lipid A.
Le Dur A, Caroff M, Chaby R, Szabó L. Le Dur A, et al. Eur J Biochem. 1978 Mar 15;84(2):579-89. doi: 10.1111/j.1432-1033.1978.tb12201.x. Eur J Biochem. 1978. PMID: 205414
The endotoxin of Bordetella pertussis was cleaved by mild acidic hydrolysis to yield a polysaccharide (polysaccharide I, 15%), a glycolipid (63%) and lipid X (2%). Further treatment of the glycolipid with stronger acid released a second polysaccharide (polysa …
The endotoxin of Bordetella pertussis was cleaved by mild acidic hydrolysis to yield a polysaccharide (polysaccharide I, 15%), a
Biological activities of fragments derived from Bordetella pertussis endotoxin: isolation of a nontoxic, Shwartzman-negative lipid A possessing high adjuvant properties.
Ayme G, Caroff M, Chaby R, Haeffner-Cavaillon N, Le Dur A, Moreau M, Muset M, Mynard MC, Roumiantzeff M, Schulz D, Szabó L. Ayme G, et al. Among authors: le dur a. Infect Immun. 1980 Mar;27(3):739-45. doi: 10.1128/IAI.27.3.739-745.1980. Infect Immun. 1980. PMID: 6247278 Free PMC article.
Endotoxin from fresly sedimented Bordetella pertussis cells, isolated by the phenol/water procedure when submitted to kinetically controlled, mild acidic hydrolysis released a polysaccharide (polysaccharide 1), a complex lipid (lipid X), and a glycolipid. Whe …
Endotoxin from fresly sedimented Bordetella pertussis cells, isolated by the phenol/water procedure when submitted to kinetically controlled …
Isolation of two protein-free and chemically different lipopolysaccharides from Bordetella pertussis phenol-extracted endotoxin.
Le Dur A, Chaby R, Szabó L. Le Dur A, et al. J Bacteriol. 1980 Jul;143(1):78-88. doi: 10.1128/JB.143.1.78-88.1980. J Bacteriol. 1980. PMID: 6249793 Free PMC article.
Upon hydrolysis with acetic acid (pH 3.4) at 100 degrees C for 1 h, LPS-I released a polysaccharide (PS-I); the linkage broken was that of the glycosidic bond of a non-phosphorylated 3-deoxy-oct-2-ulosonic acid. Treatment with 0.25 M mineral acid at 100 degrees C fo …
Upon hydrolysis with acetic acid (pH 3.4) at 100 degrees C for 1 h, LPS-I released a polysaccharide (PS-I); the linkage broken was th …
Molecular requirement for interleukin 1 induction by lipopolysaccharide-stimulated human monocytes: involvement of the heptosyl-2-keto-3-deoxyoctulosonate region.
Lebbar S, Cavaillon JM, Caroff M, Ledur A, Brade H, Sarfati R, Haeffner-Cavaillon N. Lebbar S, et al. Eur J Immunol. 1986 Jan;16(1):87-91. doi: 10.1002/eji.1830160117. Eur J Immunol. 1986. PMID: 2419139
Similarly, the trisaccharide alpha-D-manno-heptopyranosyl-(1-3)-alpha-D-manno-heptopyranosyl -(1-5)-3 -deoxy-D-manno-octulosonic acid (hep-hep-KDO), representative for the inner-core region of a large number of enterobacterial LPS, was a very potent IL 1 inducer. .. …
Similarly, the trisaccharide alpha-D-manno-heptopyranosyl-(1-3)-alpha-D-manno-heptopyranosyl -(1-5)-3 -deoxy-D-manno-octulosonic acid (hep-h …
Lipopolysaccharide complexed with soluble CD14 binds to normal human monocytes.
Blondin C, Le Dur A, Cholley B, Caroff M, Haeffner-Cavaillon N. Blondin C, et al. Among authors: le dur a. Eur J Immunol. 1997 Dec;27(12):3303-9. doi: 10.1002/eji.1830271229. Eur J Immunol. 1997. PMID: 9464818
When cells were first saturated with a mixture of My4 and 10G33 mAb, washed and further incubated with FITC-LPS/sCD14, inhibition of the binding of LPS was similar to that observed with cells saturated with My4 alone, showing that the binding of FITC-LPS is not mediated by …
When cells were first saturated with a mixture of My4 and 10G33 mAb, washed and further incubated with FITC-LPS/sCD14, inhibition of …
Induction by lipopolysaccharide of intracellular and extracellular interleukin 1 production: analysis with synthetic models.
Lasfargues A, Ledur A, Charon D, Szabo L, Chaby R. Lasfargues A, et al. J Immunol. 1987 Jul 15;139(2):429-36. J Immunol. 1987. PMID: 3496381
Both isolated regions of this LPS (PS and Lipid A) were able to induce IL 1 synthesis by monocytes and macrophages. Among the synthetic glycolipids employed, propyl-2-deoxy-2-[(3R)-3-hydroxytetrade-canamido]-4-O-pho sph ono-6-O-tetradecanoyl-beta-D-glucopyranoside (glycoli …
Both isolated regions of this LPS (PS and Lipid A) were able to induce IL 1 synthesis by monocytes and macrophages. Among the synthet …
Selective induction of interleukin-1 receptor antagonist and interleukin-8 in human monocytes by normal polyspecific IgG (intravenous immunoglobulin).
Ruiz de Souza V, Carreno MP, Kaveri SV, Ledur A, Sadeghi H, Cavaillon JM, Kazatchkine MD, Haeffner-Cavaillon N. Ruiz de Souza V, et al. Eur J Immunol. 1995 May;25(5):1267-73. doi: 10.1002/eji.1830250521. Eur J Immunol. 1995. PMID: 7774630
We have investigated the effects of intravenous immunoglobulin (IVIg), a therapeutic preparation of normal human polyspecific IgG, on the synthesis and release of cytokines by peripheral blood monocytes. ...The addition of IVIg to cultures of purified monocytes induced …
We have investigated the effects of intravenous immunoglobulin (IVIg), a therapeutic preparation of normal human polyspecific IgG, on …
Analysis of the lipopolysaccharide-induced cytostatic activity of macrophages, by the use of synthetic models.
Lasfargues A, Charon D, Trigalo F, Ledur A, Szabo L, Chaby R. Lasfargues A, et al. Cell Immunol. 1986 Mar;98(1):8-17. doi: 10.1016/0008-8749(86)90262-5. Cell Immunol. 1986. PMID: 3091277
Informations on the structural features implicated in the macrophage-dependent cytostatic activity of "lipid A" preparations were obtained by the use of 15 synthetic glycolipids. Four structural requirements were identified: the presence of a reducing glucosamine un …
Informations on the structural features implicated in the macrophage-dependent cytostatic activity of "lipid A" preparations were obt …
Variable estimates of cytokine levels produced by commercial ELISA kits: results using international cytokine standards.
Ledur A, Fitting C, David B, Hamberger C, Cavaillon JM. Ledur A, et al. J Immunol Methods. 1995 Oct 26;186(2):171-9. doi: 10.1016/0022-1759(95)00184-c. J Immunol Methods. 1995. PMID: 7594617
A wide variation in values was obtained when measurements were deduced from the standard curves formed with the standard provided by the manufacturers. ...
A wide variation in values was obtained when measurements were deduced from the standard curves formed with the standard provided by
Plasma levels of monocyte chemoattractant protein-1 but not those of macrophage inhibitory protein-1alpha and RANTES correlate with virus load in human immunodeficiency virus infection.
Weiss L, Si-Mohamed A, Giral P, Castiel P, Ledur A, Blondin C, Kazatchkine MD, Haeffner-Cavaillon N. Weiss L, et al. J Infect Dis. 1997 Dec;176(6):1621-4. doi: 10.1086/517341. J Infect Dis. 1997. PMID: 9395378
Since MCP-1 upregulates viral replication in vitro, the results may suggest a role for MCP-1 in triggering viral replication in HIV disease....
Since MCP-1 upregulates viral replication in vitro, the results may suggest a role for MCP-1 in triggering viral replication in HIV d …
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