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Nicotinic receptors at the amino acid level.
Corringer PJ, Le Novère N, Changeux JP. Corringer PJ, et al. Among authors: le novere n. Annu Rev Pharmacol Toxicol. 2000;40:431-58. doi: 10.1146/annurev.pharmtox.40.1.431. Annu Rev Pharmacol Toxicol. 2000. PMID: 10836143 Review.
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism.
Taly A, Delarue M, Grutter T, Nilges M, Le Novère N, Corringer PJ, Changeux JP. Taly A, et al. Among authors: le novere n. Biophys J. 2005 Jun;88(6):3954-65. doi: 10.1529/biophysj.104.050229. Epub 2005 Apr 1. Biophys J. 2005. PMID: 15805177 Free PMC article.
Rational understanding of nicotinic receptors drug binding.
Grutter T, Le Novère N, Changeux JP. Grutter T, et al. Among authors: le novere n. Curr Top Med Chem. 2004;4(6):645-50. doi: 10.2174/1568026043451177. Curr Top Med Chem. 2004. PMID: 14965300 Review.
An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine.
Sallette J, Bohler S, Benoit P, Soudant M, Pons S, Le Novère N, Changeux JP, Corringer PJ. Sallette J, et al. Among authors: le novere n. J Biol Chem. 2004 Apr 30;279(18):18767-75. doi: 10.1074/jbc.M308260200. Epub 2004 Feb 5. J Biol Chem. 2004. PMID: 14764595
Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice.
Champtiaux N, Gotti C, Cordero-Erausquin M, David DJ, Przybylski C, Léna C, Clementi F, Moretti M, Rossi FM, Le Novère N, McIntosh JM, Gardier AM, Changeux JP. Champtiaux N, et al. Among authors: le novere n. J Neurosci. 2003 Aug 27;23(21):7820-9. doi: 10.1523/JNEUROSCI.23-21-07820.2003. J Neurosci. 2003. PMID: 12944511 Free PMC article.
An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors.
Grutter T, Prado de Carvalho L, Le Novère N, Corringer PJ, Edelstein S, Changeux JP. Grutter T, et al. Among authors: le novere n. EMBO J. 2003 May 1;22(9):1990-2003. doi: 10.1093/emboj/cdg197. EMBO J. 2003. PMID: 12727867 Free PMC article.
Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]alpha-bungarotoxin binding sites in the brain of Macaca mulatta.
Han ZY, Zoli M, Cardona A, Bourgeois JP, Changeux JP, Le Novère N. Han ZY, et al. Among authors: le novere n. J Comp Neurol. 2003 Jun 16;461(1):49-60. doi: 10.1002/cne.10659. J Comp Neurol. 2003. PMID: 12722104
The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences.
Le Novère N, Corringer PJ, Changeux JP. Le Novère N, et al. J Neurobiol. 2002 Dec;53(4):447-56. doi: 10.1002/neu.10153. J Neurobiol. 2002. PMID: 12436412 Review.
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.
Le Novère N, Grutter T, Changeux JP. Le Novère N, et al. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3210-5. doi: 10.1073/pnas.042699699. Epub 2002 Feb 26. Proc Natl Acad Sci U S A. 2002. PMID: 11867716 Free PMC article.
Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor.
Fruchart-Gaillard C, Gilquin B, Antil-Delbeke S, Le Novère N, Tamiya T, Corringer PJ, Changeux JP, Ménez A, Servent D. Fruchart-Gaillard C, et al. Among authors: le novere n. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3216-21. doi: 10.1073/pnas.042699899. Epub 2002 Feb 26. Proc Natl Acad Sci U S A. 2002. PMID: 11867717 Free PMC article.
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