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13 results
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C-Myc 5' untranslated region contains an internal ribosome entry segment.
Stoneley M, Paulin FE, Le Quesne JP, Chappell SA, Willis AE. Stoneley M, et al. Among authors: le quesne jp. Oncogene. 1998 Jan 22;16(3):423-8. doi: 10.1038/sj.onc.1201763. Oncogene. 1998. PMID: 9467968 Free article.
Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment.
Stoneley M, Subkhankulova T, Le Quesne JP, Coldwell MJ, Jopling CL, Belsham GJ, Willis AE. Stoneley M, et al. Among authors: le quesne jp. Nucleic Acids Res. 2000 Feb 1;28(3):687-94. doi: 10.1093/nar/28.3.687. Nucleic Acids Res. 2000. PMID: 10637319 Free PMC article.
A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation.
Chappell SA, LeQuesne JP, Paulin FE, deSchoolmeester ML, Stoneley M, Soutar RL, Ralston SH, Helfrich MH, Willis AE. Chappell SA, et al. Oncogene. 2000 Sep 7;19(38):4437-40. doi: 10.1038/sj.onc.1203791. Oncogene. 2000. PMID: 10980620 Free article.
Derivation of a structural model for the c-myc IRES.
Le Quesne JP, Stoneley M, Fraser GA, Willis AE. Le Quesne JP, et al. J Mol Biol. 2001 Jun 29;310(1):111-26. doi: 10.1006/jmbi.2001.4745. J Mol Biol. 2001. PMID: 11419940
Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry.
Mitchell SA, Spriggs KA, Bushell M, Evans JR, Stoneley M, Le Quesne JP, Spriggs RV, Willis AE. Mitchell SA, et al. Among authors: le quesne jp. Genes Dev. 2005 Jul 1;19(13):1556-71. doi: 10.1101/gad.339105. Genes Dev. 2005. PMID: 15998809 Free PMC article.
The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.
Modelska A, Turro E, Russell R, Beaton J, Sbarrato T, Spriggs K, Miller J, Gräf S, Provenzano E, Blows F, Pharoah P, Caldas C, Le Quesne J. Modelska A, et al. Cell Death Dis. 2015 Jan 22;6(1):e1603. doi: 10.1038/cddis.2014.542. Cell Death Dis. 2015. PMID: 25611378 Free PMC article.
Resistance to HSP90 inhibition involving loss of MCL1 addiction.
Busacca S, Law EW, Powley IR, Proia DA, Sequeira M, Le Quesne J, Klabatsa A, Edwards JM, Matchett KB, Luo JL, Pringle JH, El-Tanani M, MacFarlane M, Fennell DA. Busacca S, et al. Oncogene. 2016 Mar 24;35(12):1483-92. doi: 10.1038/onc.2015.213. Epub 2015 Jun 22. Oncogene. 2016. PMID: 26096930 Free PMC article.
eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes.
Waldron JA, Raza F, Le Quesne J. Waldron JA, et al. Nucleic Acids Res. 2018 Apr 6;46(6):3075-3087. doi: 10.1093/nar/gky108. Nucleic Acids Res. 2018. PMID: 29471358 Free PMC article.
Molecular characteristics of screen-detected vs symptomatic breast cancers and their impact on survival.
Dawson SJ, Duffy SW, Blows FM, Driver KE, Provenzano E, LeQuesne J, Greenberg DC, Pharoah P, Caldas C, Wishart GC. Dawson SJ, et al. Br J Cancer. 2009 Oct 20;101(8):1338-44. doi: 10.1038/sj.bjc.6605317. Epub 2009 Sep 22. Br J Cancer. 2009. PMID: 19773756 Free PMC article.
Dysregulation of protein synthesis and disease.
Le Quesne JP, Spriggs KA, Bushell M, Willis AE. Le Quesne JP, et al. J Pathol. 2010 Jan;220(2):140-51. doi: 10.1002/path.2627. J Pathol. 2010. PMID: 19827082 Review.
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