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Small RNAs in streptococci.
Le Rhun A, Charpentier E. Le Rhun A, et al. RNA Biol. 2012 Apr;9(4):414-26. doi: 10.4161/rna.20104. Epub 2012 Apr 1. RNA Biol. 2012. PMID: 22546939 Review.
Here, we provide a comprehensive summary of the information available on the topic....
Here, we provide a comprehensive summary of the information available on the topic....
The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems.
Chylinski K, Le Rhun A, Charpentier E. Chylinski K, et al. RNA Biol. 2013 May;10(5):726-37. doi: 10.4161/rna.24321. Epub 2013 Apr 5. RNA Biol. 2013. PMID: 23563642 Free PMC article.
CRISPR-Cas is a rapidly evolving RNA-mediated adaptive immune system that protects bacteria and archaea against mobile genetic elements. ...A set of CRISPR-Cas, type II, requires a trans-activating small RNA, tracrRNA, for maturation of precursor crRNA (pre-c …
CRISPR-Cas is a rapidly evolving RNA-mediated adaptive immune system that protects bacteria and archaea against mobile genetic elemen …
Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems.
Fonfara I, Le Rhun A, Chylinski K, Makarova KS, Lécrivain AL, Bzdrenga J, Koonin EV, Charpentier E. Fonfara I, et al. Nucleic Acids Res. 2014 Feb;42(4):2577-90. doi: 10.1093/nar/gkt1074. Epub 2013 Nov 22. Nucleic Acids Res. 2014. PMID: 24270795 Free PMC article.
The CRISPR-Cas-derived RNA-guided Cas9 endonuclease is the key element of an emerging promising technology for genome engineering in a broad range of cells and organisms. The DNA-targeting mechanism of the type II CRISPR-Cas system involves maturation of tracrRNA:crRNA dup …
The CRISPR-Cas-derived RNA-guided Cas9 endonuclease is the key element of an emerging promising technology for genome engineering in a
RNA sequencing uncovers antisense RNAs and novel small RNAs in Streptococcus pyogenes.
Le Rhun A, Beer YY, Reimegård J, Chylinski K, Charpentier E. Le Rhun A, et al. RNA Biol. 2016;13(2):177-95. doi: 10.1080/15476286.2015.1110674. RNA Biol. 2016. PMID: 26580233 Free PMC article.
Streptococcus pyogenes is a human pathogen responsible for a wide spectrum of diseases ranging from mild to life-threatening infections. During the infectious process, the temporal and spatial expression of pathogenicity factors is tightly controlled by a com …
Streptococcus pyogenes is a human pathogen responsible for a wide spectrum of diseases ranging from mild to life-threatening i …
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA.
Fonfara I, Richter H, Bratovič M, Le Rhun A, Charpentier E. Fonfara I, et al. Among authors: le rhun a. Nature. 2016 Apr 28;532(7600):517-21. doi: 10.1038/nature17945. Epub 2016 Apr 20. Nature. 2016. PMID: 27096362
A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus.
Resch U, Tsatsaronis JA, Le Rhun A, Stübiger G, Rohde M, Kasvandik S, Holzmeister S, Tinnefeld P, Wai SN, Charpentier E. Resch U, et al. Among authors: le rhun a. mBio. 2016 Nov 1;7(6):e00207-16. doi: 10.1128/mBio.00207-16. mBio. 2016. PMID: 27803183 Free PMC article.
Identification of endoribonuclease specific cleavage positions reveals novel targets of RNase III in Streptococcus pyogenes.
Le Rhun A, Lécrivain AL, Reimegård J, Proux-Wéra E, Broglia L, Della Beffa C, Charpentier E. Le Rhun A, et al. Nucleic Acids Res. 2017 Mar 17;45(5):2329-2340. doi: 10.1093/nar/gkw1316. Nucleic Acids Res. 2017. PMID: 28082390 Free PMC article.
RNase Y-mediated regulation of the streptococcal pyrogenic exotoxin B.
Broglia L, Materne S, Lécrivain AL, Hahnke K, Le Rhun A, Charpentier E. Broglia L, et al. Among authors: le rhun a. RNA Biol. 2018;15(10):1336-1347. doi: 10.1080/15476286.2018.1532253. Epub 2018 Oct 18. RNA Biol. 2018. PMID: 30290721 Free PMC article.
In vivo 3'-to-5' exoribonuclease targetomes of Streptococcus pyogenes.
Lécrivain AL, Le Rhun A, Renault TT, Ahmed-Begrich R, Hahnke K, Charpentier E. Lécrivain AL, et al. Among authors: le rhun a. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):11814-11819. doi: 10.1073/pnas.1809663115. Epub 2018 Oct 31. Proc Natl Acad Sci U S A. 2018. PMID: 30381461 Free PMC article.
CRISPR-Cas in Streptococcus pyogenes.
Le Rhun A, Escalera-Maurer A, Bratovič M, Charpentier E. Le Rhun A, et al. RNA Biol. 2019 Apr;16(4):380-389. doi: 10.1080/15476286.2019.1582974. Epub 2019 Mar 11. RNA Biol. 2019. PMID: 30856357 Free PMC article. Review.
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