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Human PXR forms a tryptophan zipper-mediated homodimer.
Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Noble SM, et al. Biochemistry. 2006 Jul 18;45(28):8579-89. doi: 10.1021/bi0602821. Biochemistry. 2006. PMID: 16834332 Free PMC article.
CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.
Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, Madan A, Parkinson A, Christ D, Selling B, LeCluyse E, Gan LS. Luo G, et al. Drug Metab Dispos. 2002 Jul;30(7):795-804. doi: 10.1124/dmd.30.7.795. Drug Metab Dispos. 2002. PMID: 12065438
117 results