LeCluyse EL - Search Results

1

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT. Jones SA, et al. Among authors: lecluyse el. Mol Endocrinol. 2000 Jan;14(1):27-39. doi: 10.1210/mend.14.1.0409. Mol Endocrinol. 2000. PMID: 10628745

2

Human PXR forms a tryptophan zipper-mediated homodimer.

Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Noble SM, et al. Biochemistry. 2006 Jul 18;45(28):8579-89. doi: 10.1021/bi0602821. Biochemistry. 2006. PMID: 16834332 Free PMC article.

3

Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.

Faucette SR, Hawke RL, Lecluyse EL, Shord SS, Yan B, Laethem RM, Lindley CM. Faucette SR, et al. Among authors: lecluyse el. Drug Metab Dispos. 2000 Oct;28(10):1222-30. Drug Metab Dispos. 2000. PMID: 10997944

4

Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.

LeCluyse EL. LeCluyse EL. Chem Biol Interact. 2001 May 16;134(3):283-9. doi: 10.1016/s0009-2797(01)00163-6. Chem Biol Interact. 2001. PMID: 11336976 Review.

5

In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone.

McCune JS, Hawke RL, LeCluyse EL, Gillenwater HH, Hamilton G, Ritchie J, Lindley C. McCune JS, et al. Among authors: lecluyse el. Clin Pharmacol Ther. 2000 Oct;68(4):356-66. doi: 10.1067/mcp.2000.110215. Clin Pharmacol Ther. 2000. PMID: 11061575 Clinical Trial.

6

Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes.

LeCluyse E, Madan A, Hamilton G, Carroll K, DeHaan R, Parkinson A. LeCluyse E, et al. J Biochem Mol Toxicol. 2000;14(4):177-88. doi: 10.1002/(sici)1099-0461(2000)14:4<177::aid-jbt1>3.0.co;2-4. J Biochem Mol Toxicol. 2000. PMID: 10789495

7

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.

Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E. Wang H, et al. J Biol Chem. 2004 Jul 9;279(28):29295-301. doi: 10.1074/jbc.M400580200. Epub 2004 Apr 28. J Biol Chem. 2004. PMID: 15123723

8

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.

Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, Madan A, Parkinson A, Christ D, Selling B, LeCluyse E, Gan LS. Luo G, et al. Drug Metab Dispos. 2002 Jul;30(7):795-804. doi: 10.1124/dmd.30.7.795. Drug Metab Dispos. 2002. PMID: 12065438

9

Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation.

Soldatow V, Peffer RC, Trask OJ, Cowie DE, Andersen ME, LeCluyse E, Deisenroth C. Soldatow V, et al. Toxicol In Vitro. 2016 Oct;36:224-237. doi: 10.1016/j.tiv.2016.08.006. Epub 2016 Aug 12. Toxicol In Vitro. 2016. PMID: 27530964

10

Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.

Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW. Sahi J, et al. Among authors: lecluyse el. Drug Metab Dispos. 2003 Apr;31(4):439-46. doi: 10.1124/dmd.31.4.439. Drug Metab Dispos. 2003. PMID: 12642470

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