LeLay J - Search Results

1

Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance.

Blanchet E, Van de Velde S, Matsumura S, Hao E, LeLay J, Kaestner K, Montminy M. Blanchet E, et al. Among authors: lelay j. Cell Rep. 2015 Feb 24;10(7):1149-57. doi: 10.1016/j.celrep.2015.01.046. Epub 2015 Feb 19. Cell Rep. 2015. PMID: 25704817 Free PMC article.

2

The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice.

Lee D, Le Lay J, Kaestner KH. Lee D, et al. Diabetologia. 2014 Jun;57(6):1242-8. doi: 10.1007/s00125-014-3203-2. Epub 2014 Mar 5. Diabetologia. 2014. PMID: 24595858

3

CREB pathway links PGE2 signaling with macrophage polarization.

Luan B, Yoon YS, Le Lay J, Kaestner KH, Hedrick S, Montminy M. Luan B, et al. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15642-7. doi: 10.1073/pnas.1519644112. Epub 2015 Dec 7. Proc Natl Acad Sci U S A. 2015. PMID: 26644581 Free PMC article.

4

CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.

Kim JH, Hedrick S, Tsai WW, Wiater E, Le Lay J, Kaestner KH, Leblanc M, Loar A, Montminy M. Kim JH, et al. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11739-11744. doi: 10.1073/pnas.1712616114. Epub 2017 Oct 16. Proc Natl Acad Sci U S A. 2017. PMID: 29078378 Free PMC article.

5

CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis.

Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH. Le Lay J, et al. Cell Metab. 2009 Jul;10(1):55-62. doi: 10.1016/j.cmet.2009.06.006. Cell Metab. 2009. PMID: 19583954 Free PMC article.

6

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver.

Everett LJ, Le Lay J, Lukovac S, Bernstein D, Steger DJ, Lazar MA, Kaestner KH. Everett LJ, et al. BMC Genomics. 2013 May 17;14:337. doi: 10.1186/1471-2164-14-337. BMC Genomics. 2013. PMID: 23682854 Free PMC article.

7

CISH has no non-redundant functions in glucose homeostasis or beta cell proliferation during pregnancy in mice.

Jiao Y, Rieck S, Le Lay J, Kaestner KH. Jiao Y, et al. Diabetologia. 2013 Nov;56(11):2435-45. doi: 10.1007/s00125-013-3014-x. Epub 2013 Aug 16. Diabetologia. 2013. PMID: 23949579 Free PMC article.

8

Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting.

Jiao Y, Le Lay J, Yu M, Naji A, Kaestner KH. Jiao Y, et al. Diabetes. 2014 Apr;63(4):1283-8. doi: 10.2337/db13-1435. Epub 2013 Dec 18. Diabetes. 2014. PMID: 24353178 Free PMC article.

9

CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells.

Shin S, Le Lay J, Everett LJ, Gupta R, Rafiq K, Kaestner KH. Shin S, et al. Mol Metab. 2014 Aug 23;3(8):803-12. doi: 10.1016/j.molmet.2014.08.001. eCollection 2014 Nov. Mol Metab. 2014. PMID: 25379405 Free PMC article.

10

Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior.

Briand LA, Lee BG, Lelay J, Kaestner KH, Blendy JA. Briand LA, et al. Among authors: lelay j. Learn Mem. 2015 Jan 15;22(2):109-15. doi: 10.1101/lm.037044.114. Print 2015 Feb. Learn Mem. 2015. PMID: 25593297 Free PMC article.

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