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Allosteric modulation of G protein-coupled receptors.
May LT, Leach K, Sexton PM, Christopoulos A. May LT, et al. Among authors: leach k. Annu Rev Pharmacol Toxicol. 2007;47:1-51. doi: 10.1146/annurev.pharmtox.47.120505.105159. Annu Rev Pharmacol Toxicol. 2007. PMID: 17009927 Review.
New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug).
Nawaratne V, Leach K, Suratman N, Loiacono RE, Felder CC, Armbruster BN, Roth BL, Sexton PM, Christopoulos A. Nawaratne V, et al. Among authors: leach k. Mol Pharmacol. 2008 Oct;74(4):1119-31. doi: 10.1124/mol.108.049353. Epub 2008 Jul 15. Mol Pharmacol. 2008. PMID: 18628403
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