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Are platelet volume indices of clinical use? A multidisciplinary review.
Leader A, Pereg D, Lishner M. Leader A, et al. Ann Med. 2012 Dec;44(8):805-16. doi: 10.3109/07853890.2011.653391. Epub 2012 Mar 13. Ann Med. 2012. PMID: 22413913 Review.
In addition, a normal platelet distribution width in the setting of thrombocytosis is highly suggestive of a reactive etiology. ...Our review provides a perspective on PVI's potential clinical use....
In addition, a normal platelet distribution width in the setting of thrombocytosis is highly suggestive of a reactive etiology …
An open-label study adding creatine monohydrate to ongoing medical regimens in patients with the fibromyalgia syndrome.
Leader A, Amital D, Rubinow A, Amital H. Leader A, et al. Ann N Y Acad Sci. 2009 Sep;1173:829-36. doi: 10.1111/j.1749-6632.2009.04811.x. Ann N Y Acad Sci. 2009. PMID: 19758235 Clinical Trial.
The aim of this open-label study was to assess the efficacy of administering a food supplement, creatine monohydrate, in an "add on" to existing therapies in patients with fibromyalgia. ...After 8 weeks of receiving creatine, we witnessed a significant improvement i …
The aim of this open-label study was to assess the efficacy of administering a food supplement, creatine monohydrate, in an "add on" …
Unrecognized renal insufficiency and chemotherapy-associated adverse effects among breast cancer patients.
Lotan E, Leader A, Lishner M, Gottfried M, Pereg D. Lotan E, et al. Among authors: leader a. Anticancer Drugs. 2012 Oct;23(9):991-5. doi: 10.1097/CAD.0b013e328355dd8a. Anticancer Drugs. 2012. PMID: 22728764
Several studies have shown that more than half of cancer patients have unrecognized renal insufficiency (RI), which is a reduced glomerular filtration rate (GFR) with normal serum creatinine. ...In total, 49 (52%) patients experienced at least one of the following chemothe …
Several studies have shown that more than half of cancer patients have unrecognized renal insufficiency (RI), which is a reduced glom …
Prevalence and Significance of Unrecognized Renal Dysfunction in Patients with Acute Coronary Syndrome.
Rozenbaum Z, Leader A, Neuman Y, Shlezinger M, Goldenberg I, Mosseri M, Pereg D. Rozenbaum Z, et al. Among authors: leader a. Am J Med. 2016 Feb;129(2):187-94. doi: 10.1016/j.amjmed.2015.08.017. Epub 2015 Sep 5. Am J Med. 2016. PMID: 26344629
CONCLUSIONS: Acute coronary syndrome patients with unrecognized renal insufficiency should be considered as a high-risk population. The question of whether this group would benefit from a more aggressive therapeutic approach should still be evaluated....
CONCLUSIONS: Acute coronary syndrome patients with unrecognized renal insufficiency should be considered as a high-risk population. T …
The Effect of Combined Aspirin and Clopidogrel Treatment on Cancer Incidence.
Leader A, Zelikson-Saporta R, Pereg D, Spectre G, Rozovski U, Raanani P, Hermoni D, Lishner M. Leader A, et al. Am J Med. 2017 Jul;130(7):826-832. doi: 10.1016/j.amjmed.2017.01.022. Epub 2017 Feb 14. Am J Med. 2017. PMID: 28213047
METHODS: A population-based historical cohort study of subjects aged50 years covered by Clalit Health Services, an Israeli health maintenance organization, was performed. ...Combined treatment was associated with a lower cancer risk than the aspirin-only group (HR 0 …
METHODS: A population-based historical cohort study of subjects aged50 years covered by Clalit Health Services, an Israeli health mai …
Mean platelet volume and risk of thrombotic and bleeding complications in patients with Philadelphia chromosome negative myeloproliferative neoplasms.
Krashin E, Cohen O, Pereg D, Lishner M, Leader A. Krashin E, et al. Among authors: leader a. Blood Coagul Fibrinolysis. 2018 Apr;29(3):288-293. doi: 10.1097/MBC.0000000000000717. Blood Coagul Fibrinolysis. 2018. PMID: 29474204
A total of 135 MPN patients met the inclusion criteria. Over a median follow-up of 6.6 years, 23 patients (15.6%) experienced thrombosis. ...Twelve patients (8.9%) had a bleeding event, whereas seven (5.2%) had major bleeding. MPV was significantly higher amo
A total of 135 MPN patients met the inclusion criteria. Over a median follow-up of 6.6 years, 23 patients (15.6%) experienced
Managing Anti-Platelet Therapy in Thrombocytopaenic Patients with Haematological Malignancy: A Multinational Clinical Vignette-Based Experiment.
Leader A, Ten Cate V, Ten Cate-Hoek AJ, Spectre G, Beckers EAM, Raanani P, Giaccherini C, Pereg D, Schouten HC, Falanga A, Ten Cate H. Leader A, et al. Thromb Haemost. 2019 Jan;119(1):163-174. doi: 10.1055/s-0038-1676520. Epub 2018 Dec 31. Thromb Haemost. 2019. PMID: 30597510
A clinical vignette-based experiment was designed. Eleven haematologists were interviewed, identifying five variable categories. ...A total of 145 physicians answered 434 cases. Clinicians were more likely to hold APT in case of 20,000/L platelets (vs. 40,000/L; RR
A clinical vignette-based experiment was designed. Eleven haematologists were interviewed, identifying five variable categories. ...
Mean platelet volume and clinical outcomes of patients with chest pain discharged from internal medicine wards.
Beeri G, Topaz G, Hershko AY, Leader A, Kitay-Cohen Y, Pereg D. Beeri G, et al. Among authors: leader a. Coron Artery Dis. 2019 Sep;30(6):455-460. doi: 10.1097/MCA.0000000000000760. Coron Artery Dis. 2019. PMID: 31094894
Each one-point increase in MPV was associated with an 11% increase in the risk for 1-year all-cause mortality (P = 0.01) and a 10% increase in the risk for 1-year ACS (P = 0.04). ...
Each one-point increase in MPV was associated with an 11% increase in the risk for 1-year all-cause mortality (P = 0.01) and a 10% in …
Thyrotropin levels within the lower normal range are associated with an increased risk of hip fractures in euthyroid women, but not men, over the age of 65 years.
Leader A, Ayzenfeld RH, Lishner M, Cohen E, Segev D, Hermoni D. Leader A, et al. J Clin Endocrinol Metab. 2014 Aug;99(8):2665-73. doi: 10.1210/jc.2013-2474. Epub 2014 Jun 2. J Clin Endocrinol Metab. 2014. PMID: 24885627
CONTEXT: The contemporary literature on the relationship between serum TSH levels and osteoporotic fractures in euthyroid individuals is limited by conflicting results and analyses conducted on a small number of fractures. ...DESIGN AND SETTING: We performed a popul …
CONTEXT: The contemporary literature on the relationship between serum TSH levels and osteoporotic fractures in euthyroid individuals is lim …
Antithrombotic medication in cancer-associated thrombocytopenia: Current evidence and knowledge gaps.
Leader A, Ten Cate H, Spectre G, Beckers EAM, Falanga A. Leader A, et al. Crit Rev Oncol Hematol. 2018 Dec;132:76-88. doi: 10.1016/j.critrevonc.2018.09.014. Epub 2018 Sep 29. Crit Rev Oncol Hematol. 2018. PMID: 30447929 Review.
Balancing the risks of bleeding and thrombosis during periods of thrombocytopenia represents a significant challenge. Management is informed mainly by expert opinion and several recent retrospective studies on venous thromboembolism. ...Important recent advances in knowled …
Balancing the risks of bleeding and thrombosis during periods of thrombocytopenia represents a significant challenge. Management is i …
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