Leader H - Search Results

1

Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues).

Leader H, Gordon RK, Baumgold J, Boyd VL, Newman AH, Smejkal RM, Chiang PK. Leader H, et al. J Med Chem. 1992 Apr 3;35(7):1290-5. doi: 10.1021/jm00085a017. J Med Chem. 1992. PMID: 1560441

2

Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.

Leader H, Wolfe AD, Chiang PK, Gordon RK. Leader H, et al. J Med Chem. 2002 Feb 14;45(4):902-10. doi: 10.1021/jm010196t. J Med Chem. 2002. PMID: 11831902

3

Aprophit: an irreversible antagonist for muscarinic receptors.

Newman AH, Covington J, Oleshansky M, Jackson BW, Weissman BA, Leader H, Chiang PK. Newman AH, et al. Among authors: leader h. Biochem Pharmacol. 1990 Sep 15;40(6):1357-64. doi: 10.1016/0006-2952(90)90404-9. Biochem Pharmacol. 1990. PMID: 2403389

4

Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.

Leader H, Smejkal RM, Payne CS, Padilla FN, Doctor BP, Gordon RK, Chiang PK. Leader H, et al. J Med Chem. 1989 Jul;32(7):1522-8. doi: 10.1021/jm00127a020. J Med Chem. 1989. PMID: 2738887

5

Synthesis and antimuscarinic activity of 2-[N-(ethyl)-(N-beta-hydroxyethyl)]aminoethyl 2,2-diphenylpropionate, a metabolite of aprophen.

Brown ND, Leader H, Phillips LR, Smejkal RM, Gordon RK, Chiang PK. Brown ND, et al. Among authors: leader h. J Pharm Sci. 1993 Jun;82(6):563-4. doi: 10.1002/jps.2600820603. J Pharm Sci. 1993. PMID: 8331525

6

Isolation and identification of beta-hydroxyethylaprophen: a urinary metabolite of aprophen in rats.

Brown ND, Phillips LR, Leader H, Chiang PK. Brown ND, et al. Among authors: leader h. J Chromatogr. 1991 Feb 15;563(2):466-71. doi: 10.1016/0378-4347(91)80057-j. J Chromatogr. 1991. PMID: 2056011

7

Pro-2-PAM therapy for central and peripheral cholinesterases.

Demar JC, Clarkson ED, Ratcliffe RH, Campbell AJ, Thangavelu SG, Herdman CA, Leader H, Schulz SM, Marek E, Medynets MA, Ku TC, Evans SA, Khan FA, Owens RR, Nambiar MP, Gordon RK. Demar JC, et al. Among authors: leader h. Chem Biol Interact. 2010 Sep 6;187(1-3):191-8. doi: 10.1016/j.cbi.2010.02.015. Epub 2010 Feb 13. Chem Biol Interact. 2010. PMID: 20156430 Free PMC article.

8

Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators.

Ashani Y, Bhattacharjee AK, Leader H, Saxena A, Doctor BP. Ashani Y, et al. Among authors: leader h. Biochem Pharmacol. 2003 Jul 15;66(2):191-202. doi: 10.1016/s0006-2952(03)00204-1. Biochem Pharmacol. 2003. PMID: 12826262

9

In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.

Ashani Y, Leader H, Raveh L, Bruckstein R, Spiegelstein M. Ashani Y, et al. Among authors: leader h. J Med Chem. 1983 Feb;26(2):145-52. doi: 10.1021/jm00356a006. J Med Chem. 1983. PMID: 6827532

10

Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime.

Luo C, Saxena A, Ashani Y, Leader H, Radić Z, Taylor P, Doctor BP. Luo C, et al. Among authors: leader h. Chem Biol Interact. 1999 May 14;119-120:129-35. doi: 10.1016/s0009-2797(99)00021-6. Chem Biol Interact. 1999. PMID: 10421446 Review.

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