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Rac1 expression by fibroblasts is required for tissue repair in vivo.
Liu S, Kapoor M, Leask A. Liu S, et al. Am J Pathol. 2009 May;174(5):1847-56. doi: 10.2353/ajpath.2009.080779. Epub 2009 Apr 6. Am J Pathol. 2009. PMID: 19349358 Free PMC article.
Tissue repair requires that fibroblasts migrate into the wound to produce and remodel extracellular matrix, a process that requires adhesion. ...Both in vivo and in vitro, Rac1- deficient fibroblasts showed a reduced generation of reactive oxygen species; in vitro, …
Tissue repair requires that fibroblasts migrate into the wound to produce and remodel extracellular matrix, a process that requires a …
Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
Xu SW, Howat SL, Renzoni EA, Holmes A, Pearson JD, Dashwood MR, Bou-Gharios G, Denton CP, du Bois RM, Black CM, Leask A, Abraham DJ. Xu SW, et al. J Biol Chem. 2004 May 28;279(22):23098-103. doi: 10.1074/jbc.M311430200. Epub 2004 Mar 23. J Biol Chem. 2004. PMID: 15044479
The endothelins are a family of endothelium-derived peptides that possess a variety of biological activities, including potent vasoconstriction. ...Our results suggest that ET-1 induces a program of matrix synthesis in lung fibroblasts and that ET-1 may play …
The endothelins are a family of endothelium-derived peptides that possess a variety of biological activities, including potent …
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
Shi-Wen X, Chen Y, Denton CP, Eastwood M, Renzoni EA, Bou-Gharios G, Pearson JD, Dashwood M, du Bois RM, Black CM, Leask A, Abraham DJ. Shi-Wen X, et al. Mol Biol Cell. 2004 Jun;15(6):2707-19. doi: 10.1091/mbc.e03-12-0902. Epub 2004 Mar 26. Mol Biol Cell. 2004. PMID: 15047866 Free PMC article.
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. ...We confirm that ET-1 enhances the ability of lung fibroblasts to contract extracellular matrix, a function essential for tissue re …
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. …
Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
Chen Y, Shi-Wen X, van Beek J, Kennedy L, McLeod M, Renzoni EA, Bou-Gharios G, Wilcox-Adelman S, Goetinck PF, Eastwood M, Black CM, Abraham DJ, Leask A. Chen Y, et al. Am J Pathol. 2005 Dec;167(6):1699-711. doi: 10.1016/s0002-9440(10)61252-7. Am J Pathol. 2005. PMID: 16314481 Free PMC article.
TGFbeta could not induce a contractile phenotype or phosphorylate ERK in syndecan 4(-/-) dermal fibroblasts. These results suggest that integrating TGFbeta and ERK signals via syndecan 4 is essential for the contractile ability of dermal fibroblasts. ...
TGFbeta could not induce a contractile phenotype or phosphorylate ERK in syndecan 4(-/-) dermal fibroblasts. These results suggest th …
The induction of CCN2 by TGFbeta1 involves Ets-1.
Van Beek JP, Kennedy L, Rockel JS, Bernier SM, Leask A. Van Beek JP, et al. Arthritis Res Ther. 2006;8(2):R36. doi: 10.1186/ar1890. Epub 2006 Jan 16. Arthritis Res Ther. 2006. PMID: 16469114 Free PMC article.
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A. Shi-wen X, et al. J Biol Chem. 2006 Apr 21;281(16):10715-26. doi: 10.1074/jbc.M511343200. Epub 2006 Feb 16. J Biol Chem. 2006. PMID: 16484225
CCN2 has been proposed to be a downstream mediator of TGFbeta action in fibroblasts; however, the role of CCN2 in regulating this process unclear. By using embryonic fibroblasts isolated from ccn2-/- mice, we showed that CCN2 is required for a subset of responses to …
CCN2 has been proposed to be a downstream mediator of TGFbeta action in fibroblasts; however, the role of CCN2 in regulating this pro …
TGFbeta, cardiac fibroblasts, and the fibrotic response.
Leask A. Leask A. Cardiovasc Res. 2007 May 1;74(2):207-12. doi: 10.1016/j.cardiores.2006.07.012. Epub 2006 Jul 21. Cardiovasc Res. 2007. PMID: 16919613 Review.
The cytokine transforming growth factor beta (TGFbeta) is a major contributor to fibrogenic responses both in vitro and in vivo. ...Recent experiments, however, have begun to elucidate the signaling pathways through which TGFbeta activates a fibrotic program. ...
The cytokine transforming growth factor beta (TGFbeta) is a major contributor to fibrogenic responses both in vitro and in vivo. ...R …
All in the CCN family: essential matricellular signaling modulators emerge from the bunker.
Leask A, Abraham DJ. Leask A, et al. J Cell Sci. 2006 Dec 1;119(Pt 23):4803-10. doi: 10.1242/jcs.03270. J Cell Sci. 2006. PMID: 17130294 Review.
The CCN family is a group of six secreted proteins that specifically associate with the extracellular matrix. Structurally, CCN proteins are modular, containing up to four distinct functional domains. ...Furthermore, in addition to having inherent adhesive abilities that m …
The CCN family is a group of six secreted proteins that specifically associate with the extracellular matrix. Structurally, CCN prote …
CCN2 is necessary for the function of mouse embryonic fibroblasts.
Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A. Kennedy L, et al. Exp Cell Res. 2007 Mar 10;313(5):952-64. doi: 10.1016/j.yexcr.2006.12.006. Epub 2006 Dec 23. Exp Cell Res. 2007. PMID: 17239853
Consistent with this notion, whereas ccn2+/+ MEFs displayed actin stress fibers and focal adhesions at the cell periphery consistent with a migratory phenotype, ccn2-/- MEFs displayed reduced focal adhesions and actin stress fibers, and a reduced ability to transduc …
Consistent with this notion, whereas ccn2+/+ MEFs displayed actin stress fibers and focal adhesions at the cell periphery consistent with …
FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.
Liu S, Xu SW, Kennedy L, Pala D, Chen Y, Eastwood M, Carter DE, Black CM, Abraham DJ, Leask A. Liu S, et al. Mol Biol Cell. 2007 Jun;18(6):2169-78. doi: 10.1091/mbc.e06-12-1121. Epub 2007 Apr 4. Mol Biol Cell. 2007. PMID: 17409352 Free PMC article.
Transforming growth factor beta (TGFbeta) plays a critical role in connective tissue remodeling by fibroblasts during development, tissue repair, and fibrosis. ...Overexpression of MEKK1, a kinase acting upstream of JNK, rescues TGFbeta responsiveness of JNK-depende …
Transforming growth factor beta (TGFbeta) plays a critical role in connective tissue remodeling by fibroblasts during development, ti …
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