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Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-13C]-Pyruvate.
Ettedgui J, Blackman B, Raju N, Kotler SA, Chekmenev EY, Goodson BM, Merkle H, Woodroofe CC, LeClair CA, Krishna MC, Swenson RE. Ettedgui J, et al. Among authors: leclair ca. J Am Chem Soc. 2024 Jan 10;146(1):946-953. doi: 10.1021/jacs.3c11499. Epub 2023 Dec 28. J Am Chem Soc. 2024. PMID: 38154120 Free PMC article.
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors.
Crawford MC, Tripu DR, Barritt SA, Jing Y, Gallimore D, Kales SC, Bhanu NV, Xiong Y, Fang Y, Butler KAT, LeClair CA, Coussens NP, Simeonov A, Garcia BA, Dibble CC, Meier JL. Crawford MC, et al. Among authors: leclair ca. ACS Chem Biol. 2023 Oct 20;18(10):2249-2258. doi: 10.1021/acschembio.3c00293. Epub 2023 Sep 22. ACS Chem Biol. 2023. PMID: 37737090
Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes.
Yan W, Zhong Y, Hu X, Xu T, Zhang Y, Kales S, Qu Y, Talley DC, Baljinnyam B, LeClair CA, Simeonov A, Polster BM, Huang R, Ye Y, Rai G, Henderson MJ, Tao D, Fang S. Yan W, et al. Among authors: leclair ca. Nat Commun. 2023 Aug 9;14(1):4798. doi: 10.1038/s41467-023-40537-x. Nat Commun. 2023. PMID: 37558718 Free PMC article.
Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors.
Crawford MC, Tripu DR, Barritt SA, Jing Y, Gallimore D, Kales SC, Bhanu NV, Xiong Y, Fang Y, Butler KAT, LeClair CA, Coussens NP, Simeonov A, Garcia BA, Dibble CC, Meier JL. Crawford MC, et al. Among authors: leclair ca. bioRxiv [Preprint]. 2023 May 16:2023.05.15.540887. doi: 10.1101/2023.05.15.540887. bioRxiv. 2023. PMID: 37292747 Free PMC article. Updated. Preprint.
An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics.
Borhani SG, Levine MZ, Krumpe LH, Wilson J, Henrich CJ, O'Keefe BR, Lo DC, Sittampalam GS, Godfrey AG, Lunsford RD, Mangalampalli V, Tao D, LeClair CA, Thole AP, Frey D, Swartz J, Rao G. Borhani SG, et al. Among authors: leclair ca. N Biotechnol. 2023 Sep 25;76:13-22. doi: 10.1016/j.nbt.2023.04.003. Epub 2023 Apr 11. N Biotechnol. 2023. PMID: 37054948 Free PMC article.
An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics.
Borhani SG, Levine MZ, Krumpe LH, Wilson J, Henrich CJ, Oâ Keefe BR, Lo D, Sittampalam GS, Godfrey AG, Lunsford RD, Mangalampalli V, Tao D, LeClair CA, Thole A, Frey D, Swartz J, Rao G. Borhani SG, et al. Among authors: leclair ca. bioRxiv [Preprint]. 2022 Dec 20:2022.12.19.521044. doi: 10.1101/2022.12.19.521044. bioRxiv. 2022. PMID: 36597541 Free PMC article. Updated. Preprint.
Rotavirus.
LeClair CE, McConnell KA. LeClair CE, et al. 2023 Jan 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jan 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32644377 Free Books & Documents.
Long-lasting insecticidal nets provide protection against malaria for only a single year in Burundi, an African highland setting with marked malaria seasonality.
Van Bortel W, Mariën J, Jacobs BKM, Sinzinkayo D, Sinarinzi P, Lampaert E, D'hondt R, Mafuko JM, De Weggheleire A, Vogt F, Alexander N, Wint W, Maes P, Vanlerberghe V, Leclair C. Van Bortel W, et al. Among authors: leclair c. BMJ Glob Health. 2022 Dec;7(12):e009674. doi: 10.1136/bmjgh-2022-009674. BMJ Glob Health. 2022. PMID: 36455989 Free PMC article.
Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen.
Clausse V, Fang Y, Tao D, Tagad HD, Sun H, Wang Y, Karavadhi S, Lane K, Shi ZD, Vasalatiy O, LeClair CA, Eells R, Shen M, Patnaik S, Appella E, Coussens NP, Hall MD, Appella DH. Clausse V, et al. Among authors: leclair ca. ACS Pharmacol Transl Sci. 2022 Sep 28;5(10):993-1006. doi: 10.1021/acsptsci.2c00147. eCollection 2022 Oct 14. ACS Pharmacol Transl Sci. 2022. PMID: 36268125 Free PMC article.
89 results