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Thrombus versus wall biological activities in experimental aortic aneurysms.
Coutard M, Touat Z, Houard X, Leclercq A, Michel JB. Coutard M, et al. Among authors: leclercq a. J Vasc Res. 2010;47(4):355-66. doi: 10.1159/000265569. Epub 2009 Dec 16. J Vasc Res. 2010. PMID: 20016209
A Methodology for Concomitant Isolation of Intimal and Adventitial Endothelial Cells from the Human Thoracic Aorta.
Leclercq A, Veillat V, Loriot S, Spuul P, Madonna F, Roques X, Génot E. Leclercq A, et al. PLoS One. 2015 Nov 24;10(11):e0143144. doi: 10.1371/journal.pone.0143144. eCollection 2015. PLoS One. 2015. PMID: 26599408 Free PMC article.
BACKGROUND: Aortic diseases are diverse and involve a multiplicity of biological systems in the vascular wall. Aortic dissection, which is usually preceded by aortic aneurysm, is a leading cause of morbidity and mortality in modern societies. ...Throughout the proce …
BACKGROUND: Aortic diseases are diverse and involve a multiplicity of biological systems in the vascular wall. Aortic dissection, whi …
Low plasma levels of HSP70 in patients with carotid atherosclerosis are associated with increased levels of proteolytic markers of neutrophil activation.
Martin-Ventura JL, Leclercq A, Blanco-Colio LM, Egido J, Rossignol P, Meilhac O, Michel JB. Martin-Ventura JL, et al. Among authors: leclercq a. Atherosclerosis. 2007 Oct;194(2):334-41. doi: 10.1016/j.atherosclerosis.2006.10.030. Epub 2006 Dec 8. Atherosclerosis. 2007. PMID: 17161406
Finally, the levels of two markers of polymorphonuclear neutrophil activation (myeloperoxidase and matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin) followed a similar trend to that observed for elastase (ELISA), and a tight positive correlation …
Finally, the levels of two markers of polymorphonuclear neutrophil activation (myeloperoxidase and matrix metalloproteinase-9/neutrophil gel …
Topology of protease activities reflects atherothrombotic plaque complexity.
Leclercq A, Houard X, Loyau S, Philippe M, Sebbag U, Meilhac O, Michel JB. Leclercq A, et al. Atherosclerosis. 2007 Mar;191(1):1-10. doi: 10.1016/j.atherosclerosis.2006.04.011. Epub 2006 May 19. Atherosclerosis. 2007. PMID: 16713600
The pathological remodeling of the arterial wall in atherosclerosis involves protease activities, which play a major role in complications, through plaque rupture. ...Results show a greater release of the plasminogen activators (PAs), plasmin and active MMPs by CPs …
The pathological remodeling of the arterial wall in atherosclerosis involves protease activities, which play a major role in complica …
Biological significance of decreased HSP27 in human atherosclerosis.
Martin-Ventura JL, Nicolas V, Houard X, Blanco-Colio LM, Leclercq A, Egido J, Vranckx R, Michel JB, Meilhac O. Martin-Ventura JL, et al. Among authors: leclercq a. Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1337-43. doi: 10.1161/01.ATV.0000220108.97208.67. Epub 2006 Mar 30. Arterioscler Thromb Vasc Biol. 2006. PMID: 16574891
CONCLUSIONS: Extracellular HSP27 can be degraded by enzymes released from atherosclerotic plaques and may reflect a proteolytic imbalance. ...HSP27 might play a pivotal role in the prevention of plaque instability and rupture....
CONCLUSIONS: Extracellular HSP27 can be degraded by enzymes released from atherosclerotic plaques and may reflect a proteolytic imbal …
Fibrinolytic activity is associated with presence of cystic medial degeneration in aneurysms of the ascending aorta.
Borges LF, Gomez D, Quintana M, Touat Z, Jondeau G, Leclercq A, Meilhac O, Jandrot-Perrus M, Gutierrez PS, Freymuller E, Vranckx R, Michel JB. Borges LF, et al. Among authors: leclercq a. Histopathology. 2010 Dec;57(6):917-32. doi: 10.1111/j.1365-2559.2010.03719.x. Histopathology. 2010. PMID: 21166705
CONCLUSIONS: The fibrinolytic pathway could play a critical role in TAA progression, via direct or indirect impact on ECM and consecutive modulation of TGF-β bioavailability....
CONCLUSIONS: The fibrinolytic pathway could play a critical role in TAA progression, via direct or indirect impact on ECM and consecu …
Involvement of intraplaque hemorrhage in atherothrombosis evolution via neutrophil protease enrichment.
Leclercq A, Houard X, Philippe M, Ollivier V, Sebbag U, Meilhac O, Michel JB. Leclercq A, et al. J Leukoc Biol. 2007 Dec;82(6):1420-9. doi: 10.1189/jlb.1106671. Epub 2007 Sep 7. J Leukoc Biol. 2007. PMID: 17827339
The pathological remodeling of the arterial wall in atherosclerosis involves protease activities, which play a major role in complications via plaque rupture. ...Addition of an elastase inhibitor at the time of incubation led to a decrease in the proMMP-9 activation …
The pathological remodeling of the arterial wall in atherosclerosis involves protease activities, which play a major role in complica …
Tissue diffusion and retention of metalloproteinases in ascending aortic aneurysms and dissections.
Borges LF, Touat Z, Leclercq A, Zen AA, Jondeau' G, Franc B, Philippe M, Meilhac O, Gutierrez PS, Michel JB. Borges LF, et al. Among authors: leclercq a. Hum Pathol. 2009 Mar;40(3):306-13. doi: 10.1016/j.humpath.2008.08.002. Epub 2008 Oct 29. Hum Pathol. 2009. PMID: 18973916
ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
Curado F, Spuul P, Egaña I, Rottiers P, Daubon T, Veillat V, Duhamel P, Leclercq A, Gontier E, Génot E. Curado F, et al. Among authors: leclercq a. Mol Cell Biol. 2014 Dec;34(24):4389-403. doi: 10.1128/MCB.01026-14. Epub 2014 Sep 29. Mol Cell Biol. 2014. PMID: 25266657 Free PMC article.
Transforming growth factor β (TGF-β) and related cytokines play a central role in the vascular system. In vitro, TGF-β induces aortic endothelial cells to assemble subcellular actin-rich structures specialized for matrix degradation called podosomes. ...
Transforming growth factor β (TGF-β) and related cytokines play a central role in the vascular system. In vitro, TGF-β induces aortic …
The MUC5AC gene: RFLP analysis with the Jer58 probe.
Pigny P, Pratt WS, Laine A, Leclercq A, Swallow DM, Nguyen VC, Aubert JP, Porchet N. Pigny P, et al. Among authors: leclercq a. Hum Genet. 1995 Sep;96(3):367-8. doi: 10.1007/BF00210427. Hum Genet. 1995. PMID: 7649560
We have recently obtained evidence that the locus corresponding to three groups of partial tracheobronchial cDNAs (A = Jer47, B = Jer57, C = Jer58) which mapped to chromosome 11p15 and was given the symbol MUC5 corresponds to two distinct genes which we have provisionally …
We have recently obtained evidence that the locus corresponding to three groups of partial tracheobronchial cDNAs (A = Jer47, B = Jer …
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