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Replication stress and cancer: it takes two to tango.
Lecona E, Fernández-Capetillo O. Lecona E, et al. Exp Cell Res. 2014 Nov 15;329(1):26-34. doi: 10.1016/j.yexcr.2014.09.019. Epub 2014 Sep 26. Exp Cell Res. 2014. PMID: 25257608 Free PMC article. Review.
Targeting ATR in cancer.
Lecona E, Fernandez-Capetillo O. Lecona E, et al. Nat Rev Cancer. 2018 Sep;18(9):586-595. doi: 10.1038/s41568-018-0034-3. Nat Rev Cancer. 2018. PMID: 29899559 Review.
Efficacy of ATR inhibitors as single agents in Ewing sarcoma.
Nieto-Soler M, Morgado-Palacin I, Lafarga V, Lecona E, Murga M, Callen E, Azorin D, Alonso J, Lopez-Contreras AJ, Nussenzweig A, Fernandez-Capetillo O. Nieto-Soler M, et al. Among authors: lecona e. Oncotarget. 2016 Sep 13;7(37):58759-58767. doi: 10.18632/oncotarget.11643. Oncotarget. 2016. PMID: 27577084 Free PMC article.
POLD3 Is Haploinsufficient for DNA Replication in Mice.
Murga M, Lecona E, Kamileri I, Díaz M, Lugli N, Sotiriou SK, Anton ME, Méndez J, Halazonetis TD, Fernandez-Capetillo O. Murga M, et al. Among authors: lecona e. Mol Cell. 2016 Sep 1;63(5):877-83. doi: 10.1016/j.molcel.2016.07.007. Epub 2016 Aug 11. Mol Cell. 2016. PMID: 27524497 Free PMC article.
USP7 is a SUMO deubiquitinase essential for DNA replication.
Lecona E, Rodriguez-Acebes S, Specks J, Lopez-Contreras AJ, Ruppen I, Murga M, Muñoz J, Mendez J, Fernandez-Capetillo O. Lecona E, et al. Nat Struct Mol Biol. 2016 Apr;23(4):270-7. doi: 10.1038/nsmb.3185. Epub 2016 Mar 7. Nat Struct Mol Biol. 2016. PMID: 26950370 Free PMC article.
NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.
Jacome A, Gutierrez-Martinez P, Schiavoni F, Tenaglia E, Martinez P, Rodríguez-Acebes S, Lecona E, Murga M, Méndez J, Blasco MA, Fernandez-Capetillo O. Jacome A, et al. Among authors: lecona e. EMBO J. 2015 Nov 3;34(21):2604-19. doi: 10.15252/embj.201591829. Epub 2015 Oct 6. EMBO J. 2015. PMID: 26443207 Free PMC article.
ERF deletion rescues RAS deficiency in mouse embryonic stem cells.
Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, Fernandez-Capetillo O. Mayor-Ruiz C, et al. Among authors: lecona e. Genes Dev. 2018 Apr 1;32(7-8):568-576. doi: 10.1101/gad.310086.117. Epub 2018 Apr 12. Genes Dev. 2018. PMID: 29650524 Free PMC article.
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