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The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response.
Iwakoshi NN, Lee AH, Glimcher LH. Iwakoshi NN, et al. Among authors: lee ah. Immunol Rev. 2003 Aug;194:29-38. doi: 10.1034/j.1600-065x.2003.00057.x. Immunol Rev. 2003. PMID: 12846805 Review.
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism.
Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH. Lee JH, et al. Among authors: lee ah. Nat Med. 2011 Jun 12;17(7):812-5. doi: 10.1038/nm.2347. Nat Med. 2011. PMID: 21666694 Free PMC article.
The role of CREB-H transcription factor in triglyceride metabolism.
Lee AH. Lee AH. Curr Opin Lipidol. 2012 Apr;23(2):141-6. doi: 10.1097/MOL.0b013e3283508fed. Curr Opin Lipidol. 2012. PMID: 22262056 Free PMC article. Review.
The transcription factor XBP1 is selectively required for eosinophil differentiation.
Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF, Glimcher LH. Bettigole SE, et al. Among authors: lee ah. Nat Immunol. 2015 Aug;16(8):829-37. doi: 10.1038/ni.3225. Epub 2015 Jul 6. Nat Immunol. 2015. PMID: 26147683 Free PMC article.
Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway.
Wang ZV, Deng Y, Gao N, Pedrozo Z, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang N, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen PPA, Ferdous A, Gillette TG, Scherer PE, Hill JA. Wang ZV, et al. Among authors: lee ah. Cell. 2014 Mar 13;156(6):1179-1192. doi: 10.1016/j.cell.2014.01.014. Cell. 2014. PMID: 24630721 Free PMC article.
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.
Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH. Cubillos-Ruiz JR, et al. Among authors: lee ah. Cell. 2015 Jun 18;161(7):1527-38. doi: 10.1016/j.cell.2015.05.025. Epub 2015 Jun 11. Cell. 2015. PMID: 26073941 Free PMC article.
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.
Jurczak MJ, Lee AH, Jornayvaz FR, Lee HY, Birkenfeld AL, Guigni BA, Kahn M, Samuel VT, Glimcher LH, Shulman GI. Jurczak MJ, et al. Among authors: lee ah, lee hy. J Biol Chem. 2012 Jan 20;287(4):2558-67. doi: 10.1074/jbc.M111.316760. Epub 2011 Nov 28. J Biol Chem. 2012. PMID: 22128176 Free PMC article.
IRE1α activation protects mice against acetaminophen-induced hepatotoxicity.
Hur KY, So JS, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Iwawaki T, Glimcher LH, Lee AH. Hur KY, et al. Among authors: lee ah. J Exp Med. 2012 Feb 13;209(2):307-18. doi: 10.1084/jem.20111298. Epub 2012 Jan 30. J Exp Med. 2012. PMID: 22291093 Free PMC article.
XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum.
Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee AH, Shi G, Konieczny SF, Glimcher LH, Mills JC. Huh WJ, et al. Among authors: lee ah. Gastroenterology. 2010 Dec;139(6):2038-49. doi: 10.1053/j.gastro.2010.08.050. Epub 2010 Oct 14. Gastroenterology. 2010. PMID: 20816838 Free PMC article.
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.
Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. Romero-Ramirez L, et al. Among authors: lee ah. Cancer Res. 2004 Sep 1;64(17):5943-7. doi: 10.1158/0008-5472.CAN-04-1606. Cancer Res. 2004. PMID: 15342372
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