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Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors.
Bae J, Keskin DB, Cowens K, Lee AH, Dranoff G, Munshi NC, Anderson KC. Bae J, et al. Among authors: Lee AH. J Leuk (Los Angel). 2015 Jun;3(2):178. doi: 10.4172/2329-6917.1000178. Epub 2015 Apr 21. J Leuk (Los Angel). 2015. PMID: 27668268 Free PMC article.
Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells.
Bae J, Samur M, Munshi A, Hideshima T, Keskin D, Kimmelman A, Lee AH, Dranoff G, Anderson KC, Munshi NC. Bae J, et al. Among authors: Lee AH. Oncoimmunology. 2014 Dec 2;3(12):e970914. doi: 10.4161/21624011.2014.970914. eCollection 2014. Oncoimmunology. 2014. PMID: 25941601 Free PMC article.
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.
Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH. Cubillos-Ruiz JR, et al. Among authors: Lee AH. Cell. 2015 Jun 18;161(7):1527-38. doi: 10.1016/j.cell.2015.05.025. Epub 2015 Jun 11. Cell. 2015. PMID: 26073941 Free PMC article.
IRE1α activation protects mice against acetaminophen-induced hepatotoxicity.
Hur KY, So JS, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Iwawaki T, Glimcher LH, Lee AH. Hur KY, et al. Among authors: Lee AH. J Exp Med. 2012 Feb 13;209(2):307-18. doi: 10.1084/jem.20111298. Epub 2012 Jan 30. J Exp Med. 2012. PMID: 22291093 Free PMC article.
Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice.
Hess DA, Humphrey SE, Ishibashi J, Damsz B, Lee AH, Glimcher LH, Konieczny SF. Hess DA, et al. Among authors: Lee AH. Gastroenterology. 2011 Oct;141(4):1463-72. doi: 10.1053/j.gastro.2011.06.045. Epub 2011 Jun 24. Gastroenterology. 2011. PMID: 21704586 Free PMC article.
XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum.
Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee AH, Shi G, Konieczny SF, Glimcher LH, Mills JC. Huh WJ, et al. Among authors: Lee AH. Gastroenterology. 2010 Dec;139(6):2038-49. doi: 10.1053/j.gastro.2010.08.050. Epub 2010 Oct 14. Gastroenterology. 2010. PMID: 20816838 Free PMC article.
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.
Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. Romero-Ramirez L, et al. Among authors: Lee AH. Cancer Res. 2004 Sep 1;64(17):5943-7. doi: 10.1158/0008-5472.CAN-04-1606. Cancer Res. 2004. PMID: 15342372
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