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Stress induction of GRP78/BiP and its role in cancer.
Li J, Lee AS. Li J, et al. Curr Mol Med. 2006 Feb;6(1):45-54. doi: 10.2174/156652406775574523. Curr Mol Med. 2006. PMID: 16472112 Review.
GRP78, also referred to as BiP, is a central regulator of endoplasmic reticulum (ER) function due to its roles in protein folding and assembly, targeting misfolded protein for degradation, ER Ca(2+)-binding and controlling the activation of trans-membrane ER stress sensors …
GRP78, also referred to as BiP, is a central regulator of endoplasmic reticulum (ER) function due to its roles in protein folding and …
Establishment of a Chinese hamster ovary cell line that expresses grp78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94.
Li LJ, Li X, Ferrario A, Rucker N, Liu ES, Wong S, Gomer CJ, Lee AS. Li LJ, et al. J Cell Physiol. 1992 Dec;153(3):575-82. doi: 10.1002/jcp.1041530319. J Cell Physiol. 1992. PMID: 1332981
Identification of a protein-binding site in the promoter of the human thymidine kinase gene required for the G1-S-regulated transcription.
Kim YK, Lee AS. Kim YK, et al. J Biol Chem. 1992 Feb 5;267(4):2723-7. J Biol Chem. 1992. PMID: 1370831
Substitution-mutation of this site results in constitutive expression of the neo reporter gene in serum-stimulated fibroblasts, as well as in cells arrested in mid-G1 by a temperature-sensitive mutation. ...
Substitution-mutation of this site results in constitutive expression of the neo reporter gene in serum-stimulated fibroblasts, as we …
Identification of a 10-base pair protein binding site in the promoter of the hamster H3.2 gene required for the S phase dependent increase in transcription and its interaction with a Jun-like nuclear factor.
Naeve GS, Sharma A, Lee AS. Naeve GS, et al. Cell Growth Differ. 1992 Dec;3(12):919-28. Cell Growth Differ. 1992. PMID: 1472472
The hamster histone H3.2 promoter contains an AP-1-like element (referred to as site X) that contains the sequence CGAGTCA. This site differs from the Jun/AP-1 consensus sequence by one base and is also similar to the cyclic AMP response element. ...However, the H3.2 speci …
The hamster histone H3.2 promoter contains an AP-1-like element (referred to as site X) that contains the sequence CGAGTCA. This site …
Expression of the glucose-regulated proteins (GRP94 and GRP78) in differentiated and undifferentiated mouse embryonic cells and the use of the GRP78 promoter as an expression system in embryonic cells.
Kim SK, Kim YK, Lee AS. Kim SK, et al. Differentiation. 1990 Feb;42(3):153-9. doi: 10.1111/j.1432-0436.1990.tb00756.x. Differentiation. 1990. PMID: 1692794
The GRP78 promoter has been identified as containing a strong enhancer. To test whether the GRP78 promoter is effective in directing expression of a heterologous gene in F9 cells, CAT fusion genes containing the GRP78 promoter were transfected into F9 cells. ...
The GRP78 promoter has been identified as containing a strong enhancer. To test whether the GRP78 promoter is effective in directing …
Glucose regulated protein induction and cellular resistance to oxidative stress mediated by porphyrin photosensitization.
Gomer CJ, Ferrario A, Rucker N, Wong S, Lee AS. Gomer CJ, et al. Cancer Res. 1991 Dec 15;51(24):6574-9. Cancer Res. 1991. PMID: 1835901
Elevated levels of mRNA encoding glucose regulated proteins (GRPs) as well as increases in GRP protein synthesis were observed for mouse radiation induced fibrosarcoma cells exposed to an extended (16-h) porphyrin incubation prior to light exposure. However, a short …
Elevated levels of mRNA encoding glucose regulated proteins (GRPs) as well as increases in GRP protein synthesis were observed …
A binding site for the cyclic adenosine 3',5'-monophosphate-response element-binding protein as a regulatory element in the grp78 promoter.
Alexandre S, Nakaki T, Vanhamme L, Lee AS. Alexandre S, et al. Mol Endocrinol. 1991 Dec;5(12):1862-72. doi: 10.1210/mend-5-12-1862. Mol Endocrinol. 1991. PMID: 1838791
Site-directed mutagenesis reveals that this sequence functions as a major basal level regulatory element in hamster fibroblast cells and is also necessary to maintain high promoter activity under stress-induced conditions. ...As such, complex I may consist of other …
Site-directed mutagenesis reveals that this sequence functions as a major basal level regulatory element in hamster fibroblast cells …
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