Lee BS - Search Results

1

Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis.

Lee BS, Hards K, Engelhart CA, Hasenoehrl EJ, Kalia NP, Mackenzie JS, Sviriaeva E, Chong SMS, Manimekalai MSS, Koh VH, Chan J, Xu J, Alonso S, Miller MJ, Steyn AJC, Grüber G, Schnappinger D, Berney M, Cook GM, Moraski GC, Pethe K. Lee BS, et al. EMBO Mol Med. 2021 Jan 11;13(1):e13207. doi: 10.15252/emmm.202013207. Epub 2020 Dec 7. EMBO Mol Med. 2021. PMID: 33283973 Free PMC article.

2

Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis.

Lee BS, Pethe K. Lee BS, et al. Curr Opin Pharmacol. 2018 Oct;42:22-26. doi: 10.1016/j.coph.2018.06.006. Epub 2018 Jul 17. Curr Opin Pharmacol. 2018. PMID: 30015177 Review.

3

Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria.

Lee BS, Kalia NP, Jin XEF, Hasenoehrl EJ, Berney M, Pethe K. Lee BS, et al. J Biol Chem. 2019 Feb 8;294(6):1936-1943. doi: 10.1074/jbc.RA118.005732. Epub 2018 Dec 7. J Biol Chem. 2019. PMID: 30530783 Free PMC article.

4

Targeting the cytochrome oxidases for drug development in mycobacteria.

Lee BS, Sviriaeva E, Pethe K. Lee BS, et al. Prog Biophys Mol Biol. 2020 May;152:45-54. doi: 10.1016/j.pbiomolbio.2020.02.001. Epub 2020 Feb 18. Prog Biophys Mol Biol. 2020. PMID: 32081616 Review.

5

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis.

Mackenzie JS, Lamprecht DA, Asmal R, Adamson JH, Borah K, Beste DJV, Lee BS, Pethe K, Rousseau S, Krieger I, Sacchettini JC, Glasgow JN, Steyn AJC. Mackenzie JS, et al. Among authors: lee bs. Nat Commun. 2020 Nov 30;11(1):6092. doi: 10.1038/s41467-020-19959-4. Nat Commun. 2020. PMID: 33257709 Free PMC article.

6

Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds.

Liu R, Markley L, Miller PA, Franzblau S, Shetye G, Ma R, Savková K, Mikušová K, Lee BS, Pethe K, Moraski GC, Miller MJ. Liu R, et al. Among authors: lee bs. RSC Med Chem. 2021 Jan 4;12(1):62-72. doi: 10.1039/d0md00390e. eCollection 2021 Jan 1. RSC Med Chem. 2021. PMID: 34046598 Free PMC article.

7

Structure guided generation of thieno[3,2-d]pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors.

Hopfner SM, Lee BS, Kalia NP, Miller MJ, Pethe K, Moraski GC. Hopfner SM, et al. Among authors: lee bs. RSC Med Chem. 2021 Jan 12;12(1):73-77. doi: 10.1039/d0md00398k. eCollection 2021 Jan 1. RSC Med Chem. 2021. PMID: 34046599 Free PMC article.

8

Telacebec: an investigational antibacterial for the treatment of tuberculosis (TB).

Lee BS, Pethe K. Lee BS, et al. Expert Opin Investig Drugs. 2022 Feb;31(2):139-144. doi: 10.1080/13543784.2022.2030309. Epub 2022 Jan 26. Expert Opin Investig Drugs. 2022. PMID: 35034512

9

Syntheses and Structure-Activity Relationships of N-Phenethyl-Quinazolin-4-yl-Amines as Potent Inhibitors of Cytochrome bd Oxidase in Mycobacterium tuberculosis.

Hopfner SM, Lee BS, Kalia NP, Miller MJ, Pethe K, Moraski GC. Hopfner SM, et al. Among authors: lee bs. Appl Sci (Basel). 2021 Oct;11(19):9092. doi: 10.3390/app11199092. Epub 2021 Sep 29. Appl Sci (Basel). 2021. PMID: 36698770 Free PMC article.

10

Inhibiting respiration as a novel antibiotic strategy.

Lee BS, Singh S, Pethe K. Lee BS, et al. Curr Opin Microbiol. 2023 Aug;74:102327. doi: 10.1016/j.mib.2023.102327. Epub 2023 May 24. Curr Opin Microbiol. 2023. PMID: 37235914 Free article. Review.

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