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1,355 results
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Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity.
Lee DK, George SR, O'Dowd BF. Lee DK, et al. Trends Pharmacol Sci. 2006 Apr;27(4):190-4. doi: 10.1016/j.tips.2006.02.006. Epub 2006 Mar 13. Trends Pharmacol Sci. 2006. PMID: 16530855 Review.
The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin.
Lee DK, Ferguson SS, George SR, O'Dowd BF. Lee DK, et al. Biochem Biophys Res Commun. 2010 Apr 30;395(2):185-9. doi: 10.1016/j.bbrc.2010.03.151. Epub 2010 Mar 28. Biochem Biophys Res Commun. 2010. PMID: 20353754
Modification of the terminal residue of apelin-13 antagonizes its hypotensive action.
Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR, O'Dowd BF. Lee DK, et al. Endocrinology. 2005 Jan;146(1):231-6. doi: 10.1210/en.2004-0359. Epub 2004 Oct 14. Endocrinology. 2005. PMID: 15486224
Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors.
Lee DK, Lança AJ, Cheng R, Nguyen T, Ji XD, Gobeil F Jr, Chemtob S, George SR, O'Dowd BF. Lee DK, et al. J Biol Chem. 2004 Feb 27;279(9):7901-8. doi: 10.1074/jbc.M306377200. Epub 2003 Nov 26. J Biol Chem. 2004. PMID: 14645236
Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets.
Lee DK, George SR, O'Dowd BF. Lee DK, et al. Expert Opin Ther Targets. 2002 Apr;6(2):185-202. doi: 10.1517/14728222.6.2.185. Expert Opin Ther Targets. 2002. PMID: 12223080 Review.
Continued discovery of ligands for G protein-coupled receptors.
Lee DK, George SR, O'Dowd BF. Lee DK, et al. Life Sci. 2003 Dec 5;74(2-3):293-7. doi: 10.1016/j.lfs.2003.09.016. Life Sci. 2003. PMID: 14607257 Review.
Discovery of a novel member of the histamine receptor family.
Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O'Dowd BF. Nguyen T, et al. Among authors: lee dk, lee sp. Mol Pharmacol. 2001 Mar;59(3):427-33. doi: 10.1124/mol.59.3.427. Mol Pharmacol. 2001. PMID: 11179435
Orphan G protein-coupled receptors in the CNS.
Lee DK, George SR, Evans JF, Lynch KR, O'Dowd BF. Lee DK, et al. Curr Opin Pharmacol. 2001 Feb;1(1):31-9. doi: 10.1016/s1471-4892(01)00003-0. Curr Opin Pharmacol. 2001. PMID: 11712532 Review.
Discovery and mapping of ten novel G protein-coupled receptor genes.
Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. Lee DK, et al. Gene. 2001 Sep 5;275(1):83-91. doi: 10.1016/s0378-1119(01)00651-5. Gene. 2001. PMID: 11574155
TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1.
O'Dowd BF, Lee DK, Huang W, Nguyen T, Cheng R, Liu Y, Wang B, Gershengorn MC, George SR. O'Dowd BF, et al. Among authors: lee dk. Mol Endocrinol. 2000 Jan;14(1):183-93. doi: 10.1210/mend.14.1.0407. Mol Endocrinol. 2000. PMID: 10628757
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