Lee JH - Search Results

1

The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.

Paull TT, Lee JH. Paull TT, et al. Among authors: lee jh. Cell Cycle. 2005 Jun;4(6):737-40. doi: 10.4161/cc.4.6.1715. Epub 2005 Jun 6. Cell Cycle. 2005. PMID: 15908798

2

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

Lee JH, Ghirlando R, Bhaskara V, Hoffmeyer MR, Gu J, Paull TT. Lee JH, et al. J Biol Chem. 2003 Nov 14;278(46):45171-81. doi: 10.1074/jbc.M308705200. Epub 2003 Sep 8. J Biol Chem. 2003. PMID: 12966088

3

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.

Lee JH, Paull TT. Lee JH, et al. Science. 2004 Apr 2;304(5667):93-6. doi: 10.1126/science.1091496. Science. 2004. PMID: 15064416

4

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.

Lee JH, Paull TT. Lee JH, et al. Science. 2005 Apr 22;308(5721):551-4. doi: 10.1126/science.1108297. Epub 2005 Mar 24. Science. 2005. PMID: 15790808

5

Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1.

Lee JH, Paull TT. Lee JH, et al. Methods Enzymol. 2006;408:529-39. doi: 10.1016/S0076-6879(06)08033-5. Methods Enzymol. 2006. PMID: 16793391

6

Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.

Bhaskara V, Dupré A, Lengsfeld B, Hopkins BB, Chan A, Lee JH, Zhang X, Gautier J, Zakian V, Paull TT. Bhaskara V, et al. Among authors: lee jh. Mol Cell. 2007 Mar 9;25(5):647-61. doi: 10.1016/j.molcel.2007.01.028. Mol Cell. 2007. PMID: 17349953 Free PMC article.

7

Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.

Hunt CR, Pandita RK, Laszlo A, Higashikubo R, Agarwal M, Kitamura T, Gupta A, Rief N, Horikoshi N, Baskaran R, Lee JH, Löbrich M, Paull TT, Roti Roti JL, Pandita TK. Hunt CR, et al. Among authors: lee jh. Cancer Res. 2007 Apr 1;67(7):3010-7. doi: 10.1158/0008-5472.CAN-06-4328. Cancer Res. 2007. PMID: 17409407

8

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.

Dupré A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J. Dupré A, et al. Among authors: lee jh. Nat Chem Biol. 2008 Feb;4(2):119-25. doi: 10.1038/nchembio.63. Epub 2008 Jan 6. Nat Chem Biol. 2008. PMID: 18176557 Free PMC article.

9

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.

Daniel JA, Pellegrini M, Lee JH, Paull TT, Feigenbaum L, Nussenzweig A. Daniel JA, et al. Among authors: lee jh. J Cell Biol. 2008 Dec 1;183(5):777-83. doi: 10.1083/jcb.200805154. J Cell Biol. 2008. PMID: 19047460 Free PMC article.

10

53BP1 promotes ATM activity through direct interactions with the MRN complex.

Lee JH, Goodarzi AA, Jeggo PA, Paull TT. Lee JH, et al. EMBO J. 2010 Feb 3;29(3):574-85. doi: 10.1038/emboj.2009.372. Epub 2009 Dec 10. EMBO J. 2010. PMID: 20010693 Free PMC article.

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