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Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake.
Fujino R, Hashizume K, Aoyama S, Maeda K, Ito K, Toshimoto K, Lee W, Ninomiya SI, Sugiyama Y. Fujino R, et al. Among authors: lee w. Eur J Pharm Sci. 2018 Dec 1;125:181-192. doi: 10.1016/j.ejps.2018.09.021. Epub 2018 Oct 1. Eur J Pharm Sci. 2018. PMID: 30287410
Expanded Physiologically-Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction.
Asaumi R, Menzel K, Lee W, Nunoya KI, Imawaka H, Kusuhara H, Sugiyama Y. Asaumi R, et al. Among authors: lee w. CPT Pharmacometrics Syst Pharmacol. 2019 Nov;8(11):845-857. doi: 10.1002/psp4.12457. Epub 2019 Sep 5. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31420941 Free PMC article.
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