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242 results
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Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations.
Rogan PK, Svojanovsky S, Leeder JS. Rogan PK, et al. Among authors: leeder js. Pharmacogenetics. 2003 Apr;13(4):207-18. doi: 10.1097/00008571-200304000-00005. Pharmacogenetics. 2003. PMID: 12668917
NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
Gaedigk A, Tyndale RF, Jurima-Romet M, Sellers EM, Grant DM, Leeder JS. Gaedigk A, et al. Among authors: leeder js. Pharmacogenetics. 1998 Aug;8(4):305-13. doi: 10.1097/00008571-199808000-00004. Pharmacogenetics. 1998. PMID: 9731717
Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
Leeder JS. Leeder JS. Epilepsia. 1998;39 Suppl 7:S8-16. doi: 10.1111/j.1528-1157.1998.tb01679.x. Epilepsia. 1998. PMID: 9798756 Review.
Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Kashuba AD, Nafziger AN, Kearns GL, Leeder JS, Shirey CS, Gotschall R, Gaedigk A, Bertino JS Jr. Kashuba AD, et al. Among authors: leeder js. Pharmacogenetics. 1998 Oct;8(5):403-10. doi: 10.1097/00008571-199810000-00005. Pharmacogenetics. 1998. PMID: 9825832
Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Abdel-Rahman SM, Marcucci K, Boge T, Gotschall RR, Kearns GL, Leeder JS. Abdel-Rahman SM, et al. Among authors: leeder js. Drug Metab Dispos. 1999 Jul;27(7):770-5. Drug Metab Dispos. 1999. PMID: 10383919
Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.
Kashuba AD, Nafziger AN, Kearns GL, Leeder JS, Gotschall R, Gaedigk A, Bertino JS Jr. Kashuba AD, et al. Among authors: leeder js. Pharmacogenetics. 1999 Aug;9(4):453-62. Pharmacogenetics. 1999. PMID: 10780265
Pharmacogenetics and pharmacogenomics.
Leeder JS. Leeder JS. Pediatr Clin North Am. 2001 Jun;48(3):765-81. doi: 10.1016/s0031-3955(05)70338-2. Pediatr Clin North Am. 2001. PMID: 11411304 Review.
Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations.
Gaedigk A, Casley WL, Tyndale RF, Sellers EM, Jurima-Romet M, Leeder JS. Gaedigk A, et al. Among authors: leeder js. Can J Physiol Pharmacol. 2001 Oct;79(10):841-7. Can J Physiol Pharmacol. 2001. PMID: 11697742
Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.
Pearce RE, Gotschall RR, Kearns GL, Leeder JS. Pearce RE, et al. Among authors: leeder js. Drug Metab Dispos. 2001 Dec;29(12):1548-54. Drug Metab Dispos. 2001. PMID: 11717173
Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation.
Abdel-Rahman SM, Leeder JS, Wilson JT, Gaedigk A, Gotschall RR, Medve R, Liao S, Spielberg SP, Kearns GL. Abdel-Rahman SM, et al. Among authors: leeder js. J Clin Pharmacol. 2002 Jan;42(1):24-9. doi: 10.1177/0091270002042001002. J Clin Pharmacol. 2002. PMID: 11808821
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