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The influence of complex white matter architecture on the mean diffusivity in diffusion tensor MRI of the human brain.
Vos SB, Jones DK, Jeurissen B, Viergever MA, Leemans A. Vos SB, et al. Among authors: leemans a. Neuroimage. 2012 Feb 1;59(3):2208-16. doi: 10.1016/j.neuroimage.2011.09.086. Epub 2011 Oct 8. Neuroimage. 2012. PMID: 22005591
Fractional anisotropy (FA) values are lower in such areas because of a lower directionality of diffusion on the voxel-scale, which makes the interpretation of FA less straightforward. Moreover, the interpretation of the axial and radial diffusivities is far from trivial wh …
Fractional anisotropy (FA) values are lower in such areas because of a lower directionality of diffusion on the voxel-scale, which ma …
Mathematical framework for simulating diffusion tensor MR neural fiber bundles.
Leemans A, Sijbers J, Verhoye M, Van der Linden A, Van Dyck D. Leemans A, et al. Magn Reson Med. 2005 Apr;53(4):944-53. doi: 10.1002/mrm.20418. Magn Reson Med. 2005. PMID: 15799061
Therefore, in this study a mathematical framework for simulating DT-MRI data, based on the physical properties of WM fiber bundles, is presented. We obtained a model of a WM fiber bundle by parameterizing the various features that characterize this bundle. We …
Therefore, in this study a mathematical framework for simulating DT-MRI data, based on the physical properties of WM fiber bundles, i …
In vivo diffusion tensor imaging (DTI) of brain subdivisions and vocal pathways in songbirds.
De Groof G, Verhoye M, Van Meir V, Tindemans I, Leemans A, Van der Linden A. De Groof G, et al. Among authors: leemans a. Neuroimage. 2006 Feb 1;29(3):754-63. doi: 10.1016/j.neuroimage.2005.09.022. Epub 2005 Oct 19. Neuroimage. 2006. PMID: 16242349
Not only does the volume of the key song control nuclei change in size, but also the density of the connections between them changes as a function of seasonal and hormonal influences. ...In vivo DTI on starling was performed on a 7T MR system using sagittal and coro …
Not only does the volume of the key song control nuclei change in size, but also the density of the connections between them changes as a
Multiscale white matter fiber tract coregistration: a new feature-based approach to align diffusion tensor data.
Leemans A, Sijbers J, De Backer S, Vandervliet E, Parizel P. Leemans A, et al. Magn Reson Med. 2006 Jun;55(6):1414-23. doi: 10.1002/mrm.20898. Magn Reson Med. 2006. PMID: 16685732
In addition, a scale-space representation of the space curves is incorporated, resulting in a multiscale robust coregistration technique. ...An in vivo coregistration example is presented and compared with a voxel-based coregistration approach, demonstrating …
In addition, a scale-space representation of the space curves is incorporated, resulting in a multiscale robust coregistration …
Gender differences and age-related white matter changes of the human brain: a diffusion tensor imaging study.
Hsu JL, Leemans A, Bai CH, Lee CH, Tsai YF, Chiu HC, Chen WH. Hsu JL, et al. Among authors: leemans a. Neuroimage. 2008 Jan 15;39(2):566-77. doi: 10.1016/j.neuroimage.2007.09.017. Epub 2007 Sep 20. Neuroimage. 2008. PMID: 17951075
We studied sixteen regions of interest in both hemispheres to search for regions that display age- and gender-related white matter changes and also performed a complementary voxel-based analysis without any hypothesis a priori. ...However, in contrast to males, fema …
We studied sixteen regions of interest in both hemispheres to search for regions that display age- and gender-related white matter changes a …
Microstructural maturation of the human brain from childhood to adulthood.
Lebel C, Walker L, Leemans A, Phillips L, Beaulieu C. Lebel C, et al. Among authors: leemans a. Neuroimage. 2008 Apr 15;40(3):1044-55. doi: 10.1016/j.neuroimage.2007.12.053. Epub 2008 Jan 11. Neuroimage. 2008. PMID: 18295509
Brain maturation is a complex process that continues well beyond infancy, and adolescence is thought to be a key period of brain rewiring. ...Differences observed in developmental timing suggest a pattern of maturation in which areas with fronto-temporal conn …
Brain maturation is a complex process that continues well beyond infancy, and adolescence is thought to be a key period of bra …
A tracking-based diffusion tensor imaging segmentation method for the detection of diffusion-related changes of the cervical spinal cord with aging.
Van Hecke W, Leemans A, Sijbers J, Vandervliet E, Van Goethem J, Parizel PM. Van Hecke W, et al. Among authors: leemans a. J Magn Reson Imaging. 2008 May;27(5):978-91. doi: 10.1002/jmri.21338. J Magn Reson Imaging. 2008. PMID: 18425838
In a first, DTT-based, segmentation approach, the diffusion properties are calculated on the tracts. In a second method, the diffusion properties are analyzed in the spinal cord voxels that contain a certain number of tracts. ...CONCLUSION: DTT is a ro …
In a first, DTT-based, segmentation approach, the diffusion properties are calculated on the tracts. In a second method, the d …
On the construction of an inter-subject diffusion tensor magnetic resonance atlas of the healthy human brain.
Van Hecke W, Sijbers J, D'Agostino E, Maes F, De Backer S, Vandervliet E, Parizel PM, Leemans A. Van Hecke W, et al. Among authors: leemans a. Neuroimage. 2008 Oct 15;43(1):69-80. doi: 10.1016/j.neuroimage.2008.07.006. Epub 2008 Jul 18. Neuroimage. 2008. PMID: 18678261
Consequently, there is a need for an inter-subject DTI atlas as a group specific reference frame that also contains this orientational DT information. ...The proposed methodology for constructing such an atlas is compared with a subject based DTI atlas, in wh …
Consequently, there is a need for an inter-subject DTI atlas as a group specific reference frame that also contains this orien …
On the construction of a ground truth framework for evaluating voxel-based diffusion tensor MRI analysis methods.
Van Hecke W, Sijbers J, De Backer S, Poot D, Parizel PM, Leemans A. Van Hecke W, et al. Among authors: leemans a. Neuroimage. 2009 Jul 1;46(3):692-707. doi: 10.1016/j.neuroimage.2009.02.032. Epub 2009 Mar 5. Neuroimage. 2009. PMID: 19268708
To address the lack of such a gold standard, simulated diffusion tensor data sets are developed, which can model an array of anomalies in the diffusion properties of a predefined location. ...In turn, this may possibly lead to a more standardized and reliable …
To address the lack of such a gold standard, simulated diffusion tensor data sets are developed, which can model an array of anomalie …
Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis: revisited.
Sage CA, Van Hecke W, Peeters R, Sijbers J, Robberecht W, Parizel P, Marchal G, Leemans A, Sunaert S. Sage CA, et al. Among authors: leemans a. Hum Brain Mapp. 2009 Nov;30(11):3657-75. doi: 10.1002/hbm.20794. Hum Brain Mapp. 2009. PMID: 19404990 Free PMC article.
Additionally, we performed a complementary TBSS analysis to improve our understanding and interpretation of the VBA results. ...This study provides support for the view of ALS as a multisystem disease, in which the entire frontotemporal lobe is implicated....
Additionally, we performed a complementary TBSS analysis to improve our understanding and interpretation of the VBA results. ...This …
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