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AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins.
Leff T. Leff T. Biochem Soc Trans. 2003 Feb;31(Pt 1):224-7. doi: 10.1042/bst0310224. Biochem Soc Trans. 2003. PMID: 12546690 Review.
Adiponectin and PPARγ: cooperative and interdependent actions of two key regulators of metabolism.
Astapova O, Leff T. Astapova O, et al. Among authors: leff t. Vitam Horm. 2012;90:143-62. doi: 10.1016/B978-0-12-398313-8.00006-3. Vitam Horm. 2012. PMID: 23017715 Review.
Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance.
Amin RH, Mathews ST, Camp HS, Ding L, Leff T. Amin RH, et al. Among authors: leff t. Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E28-37. doi: 10.1152/ajpendo.00446.2009. Epub 2009 Oct 20. Am J Physiol Endocrinol Metab. 2010. PMID: 19843873
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
Mottillo EP, Bloch AE, Leff T, Granneman JG. Mottillo EP, et al. Among authors: leff t. J Biol Chem. 2012 Jul 20;287(30):25038-48. doi: 10.1074/jbc.M112.374041. Epub 2012 Jun 8. J Biol Chem. 2012. PMID: 22685301 Free PMC article.
Endogenously produced adiponectin protects cardiomyocytes from hypertrophy by a PPARgamma-dependent autocrine mechanism.
Amin RH, Mathews ST, Alli A, Leff T. Amin RH, et al. Among authors: leff t. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H690-8. doi: 10.1152/ajpheart.01032.2009. Epub 2010 Jul 9. Am J Physiol Heart Circ Physiol. 2010. PMID: 20622112 Free PMC article.
Altered promoter recycling rates contribute to dominant-negative activity of human peroxisome proliferator-activated receptor-gamma mutations associated with diabetes.
Li G, Leff T. Li G, et al. Among authors: leff t. Mol Endocrinol. 2007 Apr;21(4):857-64. doi: 10.1210/me.2006-0401. Epub 2007 Jan 16. Mol Endocrinol. 2007. PMID: 17227883
AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.
Hong YH, Varanasi US, Yang W, Leff T. Hong YH, et al. Among authors: leff t. J Biol Chem. 2003 Jul 25;278(30):27495-501. doi: 10.1074/jbc.M304112200. Epub 2003 May 9. J Biol Chem. 2003. PMID: 12740371
Review: peroxisome proliferator-activated receptor-gamma and its role in the development and treatment of diabetes.
Leff T, Mathews ST, Camp HS. Leff T, et al. Exp Diabesity Res. 2004 Apr-Jun;5(2):99-109. doi: 10.1080/15438600490451668. Exp Diabesity Res. 2004. PMID: 15203881 Free PMC article. Review.
Mitogen-activated protein kinase regulates transcription of the ApoCIII gene. Involvement of the orphan nuclear receptor HNF4.
Reddy S, Yang W, Taylor DG, Shen Xq, Oxender D, Kust G, Leff T. Reddy S, et al. Among authors: leff t. J Biol Chem. 1999 Nov 12;274(46):33050-6. doi: 10.1074/jbc.274.46.33050. J Biol Chem. 1999. PMID: 10551874
Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors.
Yang W, Hong YH, Shen XQ, Frankowski C, Camp HS, Leff T. Yang W, et al. Among authors: leff t. J Biol Chem. 2001 Oct 19;276(42):38341-4. doi: 10.1074/jbc.C100316200. Epub 2001 Aug 22. J Biol Chem. 2001. PMID: 11518699
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