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35 results
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An EP2 receptor-selective prostaglandin E2 agonist induces bone healing.
Paralkar VM, Borovecki F, Ke HZ, Cameron KO, Lefker B, Grasser WA, Owen TA, Li M, DaSilva-Jardine P, Zhou M, Dunn RL, Dumont F, Korsmeyer R, Krasney P, Brown TA, Plowchalk D, Vukicevic S, Thompson DD. Paralkar VM, et al. Among authors: lefker b. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6736-40. doi: 10.1073/pnas.1037343100. Epub 2003 May 14. Proc Natl Acad Sci U S A. 2003. PMID: 12748385 Free PMC article.
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.
Chesworth R, Zawistoski MP, Lefker BA, Cameron KO, Day RF, Mangano FM, Rosati RL, Colella S, Petersen DN, Brault A, Lu B, Pan LC, Perry P, Ng O, Castleberry TA, Owen TA, Brown TA, Thompson DD, DaSilva-Jardine P. Chesworth R, et al. Among authors: lefker ba. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2729-33. doi: 10.1016/j.bmcl.2004.03.077. Bioorg Med Chem Lett. 2004. PMID: 15125923
Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands.
Chesworth R, Wessel MD, Heyden L, Mangano FM, Zawistoski M, Gegnas L, Galluzzo D, Lefker B, Cameron KO, Tickner J, Lu B, Castleberry TA, Petersen DN, Brault A, Perry P, Ng O, Owen TA, Pan L, Ke HZ, Brown TA, Thompson DD, DaSilva-Jardine P. Chesworth R, et al. Among authors: lefker b. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. doi: 10.1016/j.bmcl.2005.08.010. Epub 2005 Oct 10. Bioorg Med Chem Lett. 2005. PMID: 16219463
Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats.
Cameron KO, Lefker BA, Chu-Moyer MY, Crawford DT, Jardine PD, DeNinno SL, Gilbert S, Grasser WA, Ke H, Lu B, Owen TA, Paralkar VM, Qi H, Scott DO, Thompson DD, Tjoa CM, Zawistoski MP. Cameron KO, et al. Among authors: lefker ba. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1799-802. doi: 10.1016/j.bmcl.2006.01.018. Epub 2006 Jan 26. Bioorg Med Chem Lett. 2006. PMID: 16442794
A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats.
Ke HZ, Crawford DT, Qi H, Simmons HA, Owen TA, Paralkar VM, Li M, Lu B, Grasser WA, Cameron KO, Lefker BA, DaSilva-Jardine P, Scott DO, Zhang Q, Tian XY, Jee WS, Brown TA, Thompson DD. Ke HZ, et al. Among authors: lefker ba. J Bone Miner Res. 2006 Apr;21(4):565-75. doi: 10.1359/jbmr.051110. Epub 2006 Apr 5. J Bone Miner Res. 2006. PMID: 16598377
(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.
Hu LY, Du D, Hoffman J, Smith Y, Fedij V, Kostlan C, Johnson TR, Huang Y, Kesten S, Harter W, Yue WS, Li JJ, Barvian N, Mitchell L, Lei HJ, Lefker B, Carroll M, Dettling D, Krieger-Burke T, Samas B, Yalamanchili R, Lapham K, Pocalyko D, Sliskovic D, Ciotti S, Stoller B, Hena MA, Ding Q, Maiti SN, Stier M, Welgus H. Hu LY, et al. Among authors: lefker b. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5983-8. doi: 10.1016/j.bmcl.2007.07.075. Epub 2007 Aug 21. Bioorg Med Chem Lett. 2007. PMID: 17827000
Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.
Li JJ, Iula DM, Nguyen MN, Hu LY, Dettling D, Johnson TR, Du DY, Shanmugasundaram V, Van Camp JA, Wang Z, Harter WG, Yue WS, Boys ML, Wade KJ, Drummond EM, Samas BM, Lefker BA, Hoge GS, Lovdahl MJ, Asbill J, Carroll M, Meade MA, Ciotti SM, Krieger-Burke T. Li JJ, et al. J Med Chem. 2008 Nov 13;51(21):7010-4. doi: 10.1021/jm8009316. Epub 2008 Oct 16. J Med Chem. 2008. PMID: 18921992
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