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The three main stumbling blocks for anticancer T cells.
Baitsch L, Fuertes-Marraco SA, Legat A, Meyer C, Speiser DE. Baitsch L, et al. Among authors: legat a. Trends Immunol. 2012 Jul;33(7):364-72. doi: 10.1016/j.it.2012.02.006. Epub 2012 Mar 23. Trends Immunol. 2012. PMID: 22445288 Review.
Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients.
Baitsch L, Baumgaertner P, Devêvre E, Raghav SK, Legat A, Barba L, Wieckowski S, Bouzourene H, Deplancke B, Romero P, Rufer N, Speiser DE. Baitsch L, et al. Among authors: legat a. J Clin Invest. 2011 Jun;121(6):2350-60. doi: 10.1172/JCI46102. Epub 2011 May 9. J Clin Invest. 2011. PMID: 21555851 Free PMC article.
Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization.
Baitsch L, Legat A, Barba L, Fuertes Marraco SA, Rivals JP, Baumgaertner P, Christiansen-Jucht C, Bouzourene H, Rimoldi D, Pircher H, Rufer N, Matter M, Michielin O, Speiser DE. Baitsch L, et al. Among authors: legat a. PLoS One. 2012;7(2):e30852. doi: 10.1371/journal.pone.0030852. Epub 2012 Feb 8. PLoS One. 2012. PMID: 22347406 Free PMC article.
Vaccination with LAG-3Ig (IMP321) and Peptides Induces Specific CD4 and CD8 T-Cell Responses in Metastatic Melanoma Patients--Report of a Phase I/IIa Clinical Trial.
Legat A, Maby-El Hajjami H, Baumgaertner P, Cagnon L, Abed Maillard S, Geldhof C, Iancu EM, Lebon L, Guillaume P, Dojcinovic D, Michielin O, Romano E, Berthod G, Rimoldi D, Triebel F, Luescher I, Rufer N, Speiser DE. Legat A, et al. Clin Cancer Res. 2016 Mar 15;22(6):1330-40. doi: 10.1158/1078-0432.CCR-15-1212. Epub 2015 Oct 23. Clin Cancer Res. 2016. PMID: 26500235 Free article. Clinical Trial.
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