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Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2.
Cell Rep. 2021 Aug 10;36(6):109512. doi: 10.1016/j.celrep.2021.109512.
Cell Rep. 2021.
PMID: 34380038
Free PMC article.
Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human TNNT2 Variants.
Pettinato AM, Ladha FA, Mellert DJ, Legere N, Cohn R, Romano R, Thakar K, Chen YS, Hinson JT.
Pettinato AM, et al. Among authors: legere n.
Circulation. 2020 Dec 8;142(23):2262-2275. doi: 10.1161/CIRCULATIONAHA.120.047999. Epub 2020 Oct 7.
Circulation. 2020.
PMID: 33025817
Free PMC article.
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Reading Frame Repair of TTN Truncation Variants Restores Titin Quantity and Functions.
Romano R, Ghahremani S, Zimmerman T, Legere N, Thakar K, Ladha FA, Pettinato AM, Hinson JT.
Romano R, et al. Among authors: legere n.
Circulation. 2022 Jan 18;145(3):194-205. doi: 10.1161/CIRCULATIONAHA.120.049997. Epub 2021 Dec 14.
Circulation. 2022.
PMID: 34905694
Free PMC article.
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TRPM2 enhances ischemic excitotoxicity by associating with PKCγ.
Zong P, Feng J, Legere N, Li Y, Yue Z, Li CX, Mori Y, Miller B, Hao B, Yue L.
Zong P, et al. Among authors: legere n.
Cell Rep. 2024 Feb 27;43(2):113722. doi: 10.1016/j.celrep.2024.113722. Epub 2024 Feb 2.
Cell Rep. 2024.
PMID: 38308841
Free PMC article.
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CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants.
Ghahremani S, Kanwal A, Pettinato A, Ladha F, Legere N, Thakar K, Zhu Y, Tjong H, Wilderman A, Stump WT, Greenberg L, Greenberg MJ, Cotney J, Wei CL, Hinson JT.
Ghahremani S, et al. Among authors: legere n.
Circulation. 2024 Apr 16;149(16):1285-1297. doi: 10.1161/CIRCULATIONAHA.123.063972. Epub 2024 Jan 18.
Circulation. 2024.
PMID: 38235591
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Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.
Pettinato AM, Yoo D, VanOudenhove J, Chen YS, Cohn R, Ladha FA, Yang X, Thakar K, Romano R, Legere N, Meredith E, Robson P, Regnier M, Cotney JL, Murry CE, Hinson JT.
Pettinato AM, et al. Among authors: legere n.
Cell Rep. 2021 May 4;35(5):109088. doi: 10.1016/j.celrep.2021.109088.
Cell Rep. 2021.
PMID: 33951429
Free PMC article.
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