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16 results
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A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.
Legg JW, Lewis CA, Parsons M, Ng T, Isacke CM. Legg JW, et al. Nat Cell Biol. 2002 Jun;4(6):399-407. doi: 10.1038/ncb797. Nat Cell Biol. 2002. PMID: 12032545
The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events.
Thorne RF, Legg JW, Isacke CM. Thorne RF, et al. Among authors: legg jw. J Cell Sci. 2004 Jan 26;117(Pt 3):373-80. doi: 10.1242/jcs.00954. J Cell Sci. 2004. PMID: 14702383 Free article.
Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44.
Legg JW, Isacke CM. Legg JW, et al. Curr Biol. 1998 Jun 4;8(12):705-8. doi: 10.1016/s0960-9822(98)70277-5. Curr Biol. 1998. PMID: 9637922 Free article.
Discrete domains within the hyaluronan receptor CD44 regulate membrane localization and cell migration.
Sheikh H, Legg J, Lewis C, Peck D, Isacke C. Sheikh H, et al. Cell Adhes Commun. 1998;6(2-3):149-56. doi: 10.3109/15419069809004471. Cell Adhes Commun. 1998. PMID: 9823466 Review.
The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44.
Morrison H, Sherman LS, Legg J, Banine F, Isacke C, Haipek CA, Gutmann DH, Ponta H, Herrlich P. Morrison H, et al. Genes Dev. 2001 Apr 15;15(8):968-80. doi: 10.1101/gad.189601. Genes Dev. 2001. PMID: 11316791 Free PMC article.
Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture.
Estrach S, Legg J, Watt FM. Estrach S, et al. J Cell Sci. 2007 Aug 15;120(Pt 16):2944-52. doi: 10.1242/jcs.016253. Epub 2007 Jul 31. J Cell Sci. 2007. PMID: 17666427 Free PMC article.
Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis.
Legg J, Jensen UB, Broad S, Leigh I, Watt FM. Legg J, et al. Development. 2003 Dec;130(24):6049-63. doi: 10.1242/dev.00837. Epub 2003 Oct 22. Development. 2003. PMID: 14573520
Th1 cytokines are more effective than Th2 cytokines at licensing anti-tumour functions in CD40-activated human macrophages in vitro.
Luheshi N, Davies G, Poon E, Wiggins K, McCourt M, Legg J. Luheshi N, et al. Eur J Immunol. 2014 Jan;44(1):162-72. doi: 10.1002/eji.201343351. Epub 2013 Oct 16. Eur J Immunol. 2014. PMID: 24114634
Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists.
Luheshi N, Davies G, Legg J. Luheshi N, et al. Oncoimmunology. 2014 Jan 1;3(1):e27615. doi: 10.4161/onci.27615. Epub 2014 Jan 6. Oncoimmunology. 2014. PMID: 24790792 Free PMC article.
Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding.
Borrok MJ, Luheshi NM, Beyaz N, Davies GC, Legg JW, Wu H, Dall'Acqua WF, Tsui P. Borrok MJ, et al. Among authors: legg jw. MAbs. 2015;7(4):743-51. doi: 10.1080/19420862.2015.1047570. MAbs. 2015. PMID: 25970007 Free PMC article.
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