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Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.
Litzenburger UM, Opitz CA, Sahm F, Rauschenbach KJ, Trump S, Winter M, Ott M, Ochs K, Lutz C, Liu X, Anastasov N, Lehmann I, Höfer T, von Deimling A, Wick W, Platten M. Litzenburger UM, et al. Among authors: lehmann i. Oncotarget. 2014 Feb 28;5(4):1038-51. doi: 10.18632/oncotarget.1637. Oncotarget. 2014. PMID: 24657910 Free PMC article.
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.
Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M. Opitz CA, et al. Among authors: lehmann i. Nature. 2011 Oct 5;478(7368):197-203. doi: 10.1038/nature10491. Nature. 2011. PMID: 21976023 Free article.
Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism.
Murugaiyan J, Rockstroh M, Wagner J, Baumann S, Schorsch K, Trump S, Lehmann I, Bergen Mv, Tomm JM. Murugaiyan J, et al. Among authors: lehmann i. Toxicol Appl Pharmacol. 2013 Jun 15;269(3):307-16. doi: 10.1016/j.taap.2013.03.032. Epub 2013 Apr 10. Toxicol Appl Pharmacol. 2013. PMID: 23583300
Early-onset childhood atopic dermatitis is related to NLRP2 repression.
Thürmann L, Grützmann K, Klös M, Bieg M, Winter M, Polte T, Bauer T, Schick M, Bewerunge-Hudler M, Röder S, Bauer M, Wissenbach DK, Sack U, Weichenhan D, Mücke O, Plass C, Borte M, von Bergen M, Lehmann I, Eils R, Trump S. Thürmann L, et al. Among authors: lehmann i. J Allergy Clin Immunol. 2018 Apr;141(4):1482-1485.e16. doi: 10.1016/j.jaci.2017.11.018. Epub 2017 Dec 9. J Allergy Clin Immunol. 2018. PMID: 29233739 Free article. No abstract available.
DIGE-based protein expression analysis of B[a]P-exposed hepatoma cells reveals a complex stress response including alterations in oxidative stress, cell cycle control, and cytoskeleton motility at toxic and subacute concentrations.
Dautel F, Kalkhof S, Trump S, Michaelson J, Beyer A, Lehmann I, von Bergen M. Dautel F, et al. Among authors: lehmann i. J Proteome Res. 2011 Feb 4;10(2):379-93. doi: 10.1021/pr100723d. Epub 2010 Dec 21. J Proteome Res. 2011. PMID: 21171653
The benzene metabolite 1,4-benzoquinone reduces regulatory T-cell function: A potential mechanism for tobacco smoke-associated atopic dermatitis.
Winter M, Thürmann L, Gu Z, Schüürmann G, Herberth G, Hinz D, von Bergen M, Harms H, Olek S, Röder S, Borte M, Eils R, Lehmann I, Trump S. Winter M, et al. Among authors: lehmann i. J Allergy Clin Immunol. 2017 Aug;140(2):603-605. doi: 10.1016/j.jaci.2017.01.034. Epub 2017 Mar 6. J Allergy Clin Immunol. 2017. PMID: 28274748 Free article. No abstract available.
293 results