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87 results
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Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.
Wehrens XH, Lehnart SE, Reiken SR, Marks AR. Wehrens XH, et al. Among authors: lehnart se. Circ Res. 2004 Apr 2;94(6):e61-70. doi: 10.1161/01.RES.0000125626.33738.E2. Epub 2004 Mar 11. Circ Res. 2004. PMID: 15016728
Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant.
Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M, Shmerling D, Lehnart SE, Sipido KR, Kranias EG, Sanoudou D. Tzimas C, et al. Among authors: lehnart se. Cardiovasc Res. 2017 Sep 1;113(11):1403-1417. doi: 10.1093/cvr/cvx113. Cardiovasc Res. 2017. PMID: 28859293
Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure.
Lehnart SE, Wehrens XH, Marks AR. Lehnart SE, et al. Circulation. 2005 Jun 28;111(25):3342-6. doi: 10.1161/CIRCULATIONAHA.105.551861. Circulation. 2005. PMID: 15983258 Review. No abstract available.
Ryanodine receptor-targeted anti-arrhythmic therapy.
Wehrens XH, Lehnart SE, Marks AR. Wehrens XH, et al. Among authors: lehnart se. Ann N Y Acad Sci. 2005 Jun;1047:366-75. doi: 10.1196/annals.1341.032. Ann N Y Acad Sci. 2005. PMID: 16093511 Review.
Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.
Shan J, Kushnir A, Betzenhauser MJ, Reiken S, Li J, Lehnart SE, Lindegger N, Mongillo M, Mohler PJ, Marks AR. Shan J, et al. Among authors: lehnart se. J Clin Invest. 2010 Dec;120(12):4388-98. doi: 10.1172/JCI32726. Epub 2010 Nov 22. J Clin Invest. 2010. PMID: 21099118 Free PMC article.
Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins.
Muchir A, Shan J, Bonne G, Lehnart SE, Worman HJ. Muchir A, et al. Among authors: lehnart se. Hum Mol Genet. 2009 Jan 15;18(2):241-7. doi: 10.1093/hmg/ddn343. Epub 2008 Oct 16. Hum Mol Genet. 2009. PMID: 18927124 Free PMC article.
Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.
Lehnart SE, Mongillo M, Bellinger A, Lindegger N, Chen BX, Hsueh W, Reiken S, Wronska A, Drew LJ, Ward CW, Lederer WJ, Kass RS, Morley G, Marks AR. Lehnart SE, et al. J Clin Invest. 2008 Jun;118(6):2230-45. doi: 10.1172/JCI35346. J Clin Invest. 2008. PMID: 18483626 Free PMC article.
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity.
Bellinger AM, Reiken S, Dura M, Murphy PW, Deng SX, Landry DW, Nieman D, Lehnart SE, Samaru M, LaCampagne A, Marks AR. Bellinger AM, et al. Among authors: lehnart se. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2198-202. doi: 10.1073/pnas.0711074105. Epub 2008 Feb 11. Proc Natl Acad Sci U S A. 2008. PMID: 18268335 Free PMC article.
Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function.
Lehnart SE, Ackerman MJ, Benson DW Jr, Brugada R, Clancy CE, Donahue JK, George AL Jr, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, Nerbonne JM, Olson TM, Przywara DA, Towbin JA, Wang LH, Marks AR. Lehnart SE, et al. Circulation. 2007 Nov 13;116(20):2325-45. doi: 10.1161/CIRCULATIONAHA.107.711689. Circulation. 2007. PMID: 17998470
Modulation of the ryanodine receptor and intracellular calcium.
Zalk R, Lehnart SE, Marks AR. Zalk R, et al. Among authors: lehnart se. Annu Rev Biochem. 2007;76:367-85. doi: 10.1146/annurev.biochem.76.053105.094237. Annu Rev Biochem. 2007. PMID: 17506640 Review.
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