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Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice.
Lehre AC, Rowley NM, Zhou Y, Holmseth S, Guo C, Holen T, Hua R, Laake P, Olofsson AM, Poblete-Naredo I, Rusakov DA, Madsen KK, Clausen RP, Schousboe A, White HS, Danbolt NC. Lehre AC, et al. Epilepsy Res. 2011 Jun;95(1-2):70-81. doi: 10.1016/j.eplepsyres.2011.02.014. Epub 2011 Apr 3. Epilepsy Res. 2011. PMID: 21459558 Free PMC article.
Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice.
Zhou Y, Waanders LF, Holmseth S, Guo C, Berger UV, Li Y, Lehre AC, Lehre KP, Danbolt NC. Zhou Y, et al. Among authors: Lehre AC, Lehre KP. J Biol Chem. 2014 Jan 17;289(3):1329-44. doi: 10.1074/jbc.M113.529065. Epub 2013 Nov 26. J Biol Chem. 2014. PMID: 24280215 Free PMC article.
The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface.
Zhou Y, Holmseth S, Hua R, Lehre AC, Olofsson AM, Poblete-Naredo I, Kempson SA, Danbolt NC. Zhou Y, et al. Among authors: Lehre AC. Am J Physiol Renal Physiol. 2012 Feb 1;302(3):F316-28. doi: 10.1152/ajprenal.00464.2011. Epub 2011 Nov 9. Am J Physiol Renal Physiol. 2012. PMID: 22071246 Free article.