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1,799 results
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Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe.
Lei M, Baumann P, Cech TR. Lei M, et al. Biochemistry. 2002 Dec 10;41(49):14560-8. doi: 10.1021/bi026674z. Biochemistry. 2002. PMID: 12463756
Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.
Chen Y, Wan B, Wang KC, Cao F, Yang Y, Protacio A, Dou Y, Chang HY, Lei M. Chen Y, et al. Among authors: lei m. EMBO Rep. 2011 Jun 10;12(8):797-803. doi: 10.1038/embor.2011.101. EMBO Rep. 2011. PMID: 21660059 Free PMC article.
Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase.
Sowd G, Lei M, Opresko PL. Sowd G, et al. Among authors: lei m. Nucleic Acids Res. 2008 Aug;36(13):4242-56. doi: 10.1093/nar/gkn385. Epub 2008 Jun 25. Nucleic Acids Res. 2008. PMID: 18583366 Free PMC article.
Switching human telomerase on and off with hPOT1 protein in vitro.
Lei M, Zaug AJ, Podell ER, Cech TR. Lei M, et al. J Biol Chem. 2005 May 27;280(21):20449-56. doi: 10.1074/jbc.M502212200. Epub 2005 Mar 24. J Biol Chem. 2005. PMID: 15792951
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Lei M, Podell ER, Cech TR. Lei M, et al. Nat Struct Mol Biol. 2004 Dec;11(12):1223-9. doi: 10.1038/nsmb867. Epub 2004 Nov 21. Nat Struct Mol Biol. 2004. PMID: 15558049
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.
Lei M, Podell ER, Baumann P, Cech TR. Lei M, et al. Nature. 2003 Nov 13;426(6963):198-203. doi: 10.1038/nature02092. Nature. 2003. PMID: 14614509
Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex.
Ran X, Liu L, Yang CY, Lu J, Chen Y, Lei M, Wang S. Ran X, et al. Among authors: lei m. J Med Chem. 2016 Jan 14;59(1):328-34. doi: 10.1021/acs.jmedchem.5b01465. Epub 2015 Dec 29. J Med Chem. 2016. PMID: 26673461
Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA.
Zeng Z, Min B, Huang J, Hong K, Yang Y, Collins K, Lei M. Zeng Z, et al. Among authors: lei m. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20357-61. doi: 10.1073/pnas.1113624108. Epub 2011 Dec 5. Proc Natl Acad Sci U S A. 2011. PMID: 22143754 Free PMC article.
Human telomere POT1-TPP1 complex and its role in telomerase activity regulation.
Wang F, Lei M. Wang F, et al. Among authors: lei m. Methods Mol Biol. 2011;735:173-87. doi: 10.1007/978-1-61779-092-8_17. Methods Mol Biol. 2011. PMID: 21461822
Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α.
Sun J, Yang Y, Wan K, Mao N, Yu TY, Lin YC, DeZwaan DC, Freeman BC, Lin JJ, Lue NF, Lei M. Sun J, et al. Among authors: lei m. Cell Res. 2011 Feb;21(2):258-74. doi: 10.1038/cr.2010.138. Epub 2010 Sep 28. Cell Res. 2011. PMID: 20877309 Free PMC article.
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