The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis.
Freeman D, Sheaves B, Goodwin GM, Yu LM, Nickless A, Harrison PJ, Emsley R, Luik AI, Foster RG, Wadekar V, Hinds C, Gumley A, Jones R, Lightman S, Jones S, Bentall R, Kinderman P, Rowse G, Brugha T, Blagrove M, Gregory AM, Fleming L, Walklet E, Glazebrook C, Davies EB, Hollis C, Haddock G, John B, Coulson M, Fowler D, Pugh K, Cape J, Moseley P, Brown G, Hughes C, Obonsawin M, Coker S, Watkins E, Schwannauer M, MacMahon K, Siriwardena AN, Espie CA.
Freeman D, et al.
Lancet Psychiatry. 2017 Oct;4(10):749-758. doi: 10.1016/S2215-0366(17)30328-0. Epub 2017 Sep 6.
Lancet Psychiatry. 2017.
PMID: 28888927
Free PMC article.
Clinical Trial.
Compared with usual practice, the sleep intervention at 10 weeks reduced insomnia (adjusted difference 4.78, 95% CI 4.29 to 5.26, Cohen's d=1.11; p<0.0001), paranoia (-2.22, -2.98 to -1.45, Cohen's d=0.19; p<0.0001), and hallucinations (-1.58, -1.98 to -1.18, …
Compared with usual practice, the sleep intervention at 10 weeks reduced insomnia (adjusted difference 4.78, 95% CI 4.29 to 5.26, Cohen's …