Leighow SM - Search Results

1

SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics.

Wikle NB, Tran TN, Gentilesco B, Leighow SM, Albert E, Strong ER, Brinda K, Inam H, Yang F, Hossain S, Chan P, Hanage WP, Messick M, Pritchard JR, Hanks EM, Boni MF. Wikle NB, et al. Among authors: leighow sm. Sci Adv. 2022 Jan 28;8(4):eabf9868. doi: 10.1126/sciadv.abf9868. Epub 2022 Jan 26. Sci Adv. 2022. PMID: 35080987 Free PMC article.

2

Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias.

Schmitt MW, Pritchard JR, Leighow SM, Aminov BI, Beppu L, Kim DS, Hodgson JG, Rivera VM, Loeb LA, Radich JP. Schmitt MW, et al. Among authors: leighow sm. Clin Cancer Res. 2018 Nov 1;24(21):5321-5334. doi: 10.1158/1078-0432.CCR-18-0167. Epub 2018 Jul 24. Clin Cancer Res. 2018. PMID: 30042204 Free PMC article.

3

The risks of perpetuating an evolutionary arms race in drug discovery.

Leighow SM, Pritchard JR. Leighow SM, et al. Evol Med Public Health. 2019 May 21;2019(1):64-65. doi: 10.1093/emph/eoz013. eCollection 2019. Evol Med Public Health. 2019. PMID: 31186898 Free PMC article. No abstract available.

4

Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design.

Leighow SM, Liu C, Inam H, Zhao B, Pritchard JR. Leighow SM, et al. Cell Rep. 2020 Mar 24;30(12):3951-3963.e4. doi: 10.1016/j.celrep.2020.02.108. Cell Rep. 2020. PMID: 32209458 Free PMC article.

5

Optimal SARS-CoV-2 vaccine allocation using real-time seroprevalence estimates in Rhode Island and Massachusetts.

Tran TN, Wikle N, Albert J, Inam H, Strong E, Brinda K, Leighow SM, Yang F, Hossain S, Pritchard JR, Chan P, Hanage WP, Hanks EM, Boni MF. Tran TN, et al. Among authors: leighow sm. medRxiv [Preprint]. 2021 Jan 15:2021.01.12.21249694. doi: 10.1101/2021.01.12.21249694. medRxiv. 2021. PMID: 33469599 Free PMC article. Updated. Preprint.

6

Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts.

Tran TN, Wikle NB, Albert E, Inam H, Strong E, Brinda K, Leighow SM, Yang F, Hossain S, Pritchard JR, Chan P, Hanage WP, Hanks EM, Boni MF. Tran TN, et al. Among authors: leighow sm. BMC Med. 2021 Jul 13;19(1):162. doi: 10.1186/s12916-021-02038-w. BMC Med. 2021. PMID: 34253200 Free PMC article.

7

A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments.

Zhao B, Rao Y, Leighow S, O'Brien EP, Gilbert L, Pritchard JR. Zhao B, et al. Nat Commun. 2022 Feb 2;13(1):625. doi: 10.1038/s41467-022-28045-w. Nat Commun. 2022. PMID: 35110534 Free PMC article.

8

SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021.

Tran TN, Wikle NB, Yang F, Inam H, Leighow S, Gentilesco B, Chan P, Albert E, Strong ER, Pritchard JR, Hanage WP, Hanks EM, Crawford FW, Boni MF. Tran TN, et al. JAMA Netw Open. 2022 May 2;5(5):e2214171. doi: 10.1001/jamanetworkopen.2022.14171. JAMA Netw Open. 2022. PMID: 35616938 Free PMC article.

9

Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes.

Leighow SM, Landry B, Lee MJ, Peyton SR, Pritchard JR. Leighow SM, et al. Cell Mol Bioeng. 2022 Nov 15;15(5):521-533. doi: 10.1007/s12195-022-00748-6. eCollection 2022 Oct. Cell Mol Bioeng. 2022. PMID: 36444351 Free PMC article.

10

Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing.

Liu C, Leighow SM, McIlroy K, Lu M, Dennis KA, Abello K, Brown DJ, Moore CJ, Shah A, Inam H, Rivera VM, Pritchard JR. Liu C, et al. Among authors: leighow sm. Cell Rep Med. 2023 Oct 17;4(10):101227. doi: 10.1016/j.xcrm.2023.101227. Cell Rep Med. 2023. PMID: 37852183 Free PMC article.

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