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The role of ATM in response to metformin treatment and activation of AMPK.
Woods A, Leiper JM, Carling D. Woods A, et al. Among authors: leiper jm. Nat Genet. 2012 Mar 28;44(4):360-1. doi: 10.1038/ng.2235. Nat Genet. 2012. PMID: 22456733 No abstract available.
Disruption of methylarginine metabolism impairs vascular homeostasis.
Leiper J, Nandi M, Torondel B, Murray-Rust J, Malaki M, O'Hara B, Rossiter S, Anthony S, Madhani M, Selwood D, Smith C, Wojciak-Stothard B, Rudiger A, Stidwill R, McDonald NQ, Vallance P. Leiper J, et al. Nat Med. 2007 Feb;13(2):198-203. doi: 10.1038/nm1543. Epub 2007 Feb 4. Nat Med. 2007. PMID: 17273169
Intracellular localization of dimethylarginine dimethylaminohydrolase overexpressed in an endothelial cell line.
Birdsey GM, Leiper JM, Vallance P. Birdsey GM, et al. Among authors: leiper jm. Acta Physiol Scand. 2000 Jan;168(1):73-9. doi: 10.1046/j.1365-201x.2000.00672.x. Acta Physiol Scand. 2000. PMID: 10691782
Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases.
Leiper JM, Santa Maria J, Chubb A, MacAllister RJ, Charles IG, Whitley GS, Vallance P. Leiper JM, et al. Biochem J. 1999 Oct 1;343 Pt 1(Pt 1):209-14. Biochem J. 1999. PMID: 10493931 Free PMC article.
Biological significance of endogenous methylarginines that inhibit nitric oxide synthases.
Leiper J, Vallance P. Leiper J, et al. Cardiovasc Res. 1999 Aug 15;43(3):542-8. doi: 10.1016/s0008-6363(99)00162-5. Cardiovasc Res. 1999. PMID: 10690326 Review.
Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase.
Murray-Rust J, Leiper J, McAlister M, Phelan J, Tilley S, Santa Maria J, Vallance P, McDonald N. Murray-Rust J, et al. Nat Struct Biol. 2001 Aug;8(8):679-83. doi: 10.1038/90387. Nat Struct Biol. 2001. PMID: 11473257
Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia.
Lambden S, Martin D, Vanezis K, Lee B, Tomlinson J, Piper S, Boruc O, Mythen M, Leiper J. Lambden S, et al. Nitric Oxide. 2016 Aug 31;58:59-66. doi: 10.1016/j.niox.2016.06.003. Epub 2016 Jun 16. Nitric Oxide. 2016. PMID: 27319282
Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO.
Wang D, Gill PS, Chabrashvili T, Onozato ML, Raggio J, Mendonca M, Dennehy K, Li M, Modlinger P, Leiper J, Vallance P, Adler O, Leone A, Tojo A, Welch WJ, Wilcox CS. Wang D, et al. Circ Res. 2007 Sep 14;101(6):627-35. doi: 10.1161/CIRCRESAHA.107.158915. Epub 2007 Aug 2. Circ Res. 2007. PMID: 17673667
Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.
Wang Z, Lambden S, Taylor V, Sujkovic E, Nandi M, Tomlinson J, Dyson A, McDonald N, Caddick S, Singer M, Leiper J. Wang Z, et al. Biochem J. 2014 Jun 1;460(2):309-16. doi: 10.1042/BJ20131666. Biochem J. 2014. PMID: 24611830
Adenoviral-mediated overexpression of DDAH improves vascular tone regulation.
Torondel B, Nandi M, Kelly P, Wojciak-Stothard B, Fleming I, Leiper J. Torondel B, et al. Vasc Med. 2010 Jun;15(3):205-13. doi: 10.1177/1358863X09360264. Epub 2010 Mar 10. Vasc Med. 2010. PMID: 20219849
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