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Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang M, Kammertoens T, Uckert W, Blankenstein T. Leisegang M, et al. J Clin Invest. 2016 Mar 1;126(3):854-8. doi: 10.1172/JCI83465. Epub 2016 Jan 25. J Clin Invest. 2016. PMID: 26808500 Free PMC article.
Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation.
Leisegang M, Engels B, Schreiber K, Yew PY, Kiyotani K, Idel C, Arina A, Duraiswamy J, Weichselbaum RR, Uckert W, Nakamura Y, Schreiber H. Leisegang M, et al. Clin Cancer Res. 2016 Jun 1;22(11):2734-43. doi: 10.1158/1078-0432.CCR-15-2361. Epub 2015 Dec 14. Clin Cancer Res. 2016. PMID: 26667491 Free PMC article.
Targeting cancer-specific mutations by T cell receptor gene therapy.
Blankenstein T, Leisegang M, Uckert W, Schreiber H. Blankenstein T, et al. Among authors: leisegang m. Curr Opin Immunol. 2015 Apr;33:112-9. doi: 10.1016/j.coi.2015.02.005. Epub 2015 Feb 27. Curr Opin Immunol. 2015. PMID: 25728991 Free PMC article. Review.
MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors.
Leisegang M, Wilde S, Spranger S, Milosevic S, Frankenberger B, Uckert W, Schendel DJ. Leisegang M, et al. J Clin Invest. 2010 Nov;120(11):3869-77. doi: 10.1172/JCI43437. Epub 2010 Oct 11. J Clin Invest. 2010. PMID: 20978348 Free PMC article.
Targeting the epidermal growth factor receptor (HER) family by T cell receptor gene-modified T lymphocytes.
Meyerhuber P, Conrad H, Stärck L, Leisegang M, Busch DH, Uckert W, Bernhard H. Meyerhuber P, et al. Among authors: leisegang m. J Mol Med (Berl). 2010 Nov;88(11):1113-21. doi: 10.1007/s00109-010-0660-z. Epub 2010 Aug 11. J Mol Med (Berl). 2010. PMID: 20700725
T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy.
Leisegang M, Turqueti-Neves A, Engels B, Blankenstein T, Schendel DJ, Uckert W, Noessner E. Leisegang M, et al. Clin Cancer Res. 2010 Apr 15;16(8):2333-43. doi: 10.1158/1078-0432.CCR-09-2897. Epub 2010 Apr 6. Clin Cancer Res. 2010. PMID: 20371691
Designer T cells by T cell receptor replacement.
Sommermeyer D, Neudorfer J, Weinhold M, Leisegang M, Engels B, Noessner E, Heemskerk MH, Charo J, Schendel DJ, Blankenstein T, Bernhard H, Uckert W. Sommermeyer D, et al. Among authors: leisegang m. Eur J Immunol. 2006 Nov;36(11):3052-9. doi: 10.1002/eji.200636539. Eur J Immunol. 2006. PMID: 17051621
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, Ivanov A, Szymborska A, Patone G, Kunz S, Sommermeyer D, Engels B, Leisegang M, Textor A, Fehling HJ, Fruttiger M, Lohoff M, Herrmann A, Yu H, Weichselbaum R, Uckert W, Hübner N, Gerhardt H, Beule D, Schreiber H, Blankenstein T. Kammertoens T, et al. Among authors: leisegang m. Nature. 2017 May 4;545(7652):98-102. doi: 10.1038/nature22311. Epub 2017 Apr 26. Nature. 2017. PMID: 28445461 Free PMC article.
Human antitumor CD8+ T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition.
Wilde S, Sommermeyer D, Leisegang M, Frankenberger B, Mosetter B, Uckert W, Schendel DJ. Wilde S, et al. Among authors: leisegang m. J Immunol. 2012 Jul 15;189(2):598-605. doi: 10.4049/jimmunol.1102165. Epub 2012 Jun 11. J Immunol. 2012. PMID: 22689880
Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo.
Mueller K, von Mässenhausen A, Aichele U, Stärck L, Leisegang M, Uckert W, Pircher H. Mueller K, et al. Among authors: leisegang m. J Virol. 2012 Oct;86(19):10866-9. doi: 10.1128/JVI.01472-12. Epub 2012 Jul 11. J Virol. 2012. PMID: 22787223 Free PMC article.
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